TIPE2 expression is increased in peripheral blood mononuclear cells from patients with rheumatoid arthritis
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Zhu Shi-Bai1, Liu Rui-Min2, Sun Ying-Chuan2, Zhai Jie3, Jiang Chao1, Ye Can-Hua1, Chen Xi1 and Qian Wen-Wei1
1Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
2Henan University, Kaifeng, China
3Department of Breast Surgery, Cancer Institute and Hospital, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Qian Wen-Wei, email: [email protected]
Keywords: rheumatoid arthritis (RA), tumor necrosis factor-α–induced protein 8-like 2 (TIPE2), PEST-containing nuclear protein (PCNP)
Received: July 05, 2017 Accepted: September 03, 2017 Published: September 23, 2017
We investigated the changes in mRNA and protein expression of tumor necrosis factor-α–induced protein 8-like 2 (TIPE2) and PEST-containing nuclear protein (PCNP) in peripheral blood lymphocytes from 54 patients with rheumatoid arthritis (RA) and the spleens of model mice with collagen-induced arthritis (CIA) to generate new ideas for clinical diagnosis and treatment. Expression levels of both TIPE2 and PCNP were higher in RA patients and CIA mice than in their respective controls. They were also higher in the 32 patients with active RA than in the 22 with inactive RA (P < 0.001 for both). After comprehensively treating patients with active RA with anti-inflammatory and antirheumatic drugs for 6 months, they were stable, and there was no difference in TIPE2 levels between the treated patients and those with inactive RA (P = 0.85). In addition, TIPE2 mRNA levels in peripheral blood correlated positively with PCNP (R2 = 0.744, P = 0.001). The DAS28 score correlated positively with peripheral blood TIPE2 levels in the RA patients (R2 = 0.945, P = 0.001). These findings suggest TIPE2 expression increases with the severity of RA.
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