Research Papers:

Bone-strengthening pill (BSP) promotes bone cell and chondrocyte repair, and the clinical and experimental study of BSP in the treatment of osteonecrosis of the femoral head

Zheng Li, Lulin Wang _, Jin Wei, Liguo Zhu, Xisheng Weng, Jin Jin, Hong Xiao, Jun Zhang, Heming Wang, Guantong Shi, Lingpeng Pei, Fangde Zou, Wanqiang Zhang, Tianzun Tao and Xin Dong

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Oncotarget. 2017; 8:97079-97089. https://doi.org/10.18632/oncotarget.21226

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Zheng Li1,*, Lulin Wang2,*, Jin Wei3,*, Liguo Zhu4, Xisheng Weng1, Jin Jin1, Hong Xiao2, Jun Zhang4, Heming Wang5, Guantong Shi6, Lingpeng Pei7, Fangde Zou8, Wanqiang Zhang4, Tianzun Tao9 and Xin Dong10

1Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China

2Department of Orthopedics, Beijing Jianxing Traditional Chinese Medicine Hospital, Beijing, 100007, China

3Department of Dermatology and Plastic Surgery, China Aerospace 731 Hospital, Beijing, 100074, China

4Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, China

5Fujian Provincial Institute of Traditional Chinese Medicine, Fuzhou, 350003, China

6Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200021, China

7Traditional Chinese Medicine, University of MINZU, Beijing, 100081, China

8Patent Office, Tongliao Municipal Science and Technology Bureau, Tongliao, 028000, China

9Department of Orthopedics, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China

10Department of Radiology, Beijing Zhongguancun Hospital, Beijing, 100190, China

*These authors have contributed equally to the work

Correspondence to:

Lulin Wang, email: [email protected]

Xisheng Weng, email: [email protected]

Jin Jin, email: [email protected]

Keywords: osteonecrosis of femoral head, bone and cartilage, bone and joint disease, treatment, bone-strengthening pill

Received: April 04, 2017     Accepted: August 17, 2017     Published: September 23, 2017


About 1 in 3 people suffer from bone and joint disease, which is a disease of bone and cartilage cells. Osteonecrosis of the femoral head (ONFH) is a typical example of bone and joint disease involving bone cell necrosis. Osteonecrosis of the femoral head leads to the occurrence of premature osteoarthritis of the hip and collapse of the cartilage cells, and there is currently no effective drug treatment available. In order to study the effects of “bone-strengthening pill” (BSP) on the repair of bone and cartilage cells, we investigated the potential effects of the herbal mixture BSP in an animal model of avascular necrosis of the femoral head and in patients. Results showed that 90% of rats injected with prednisone developed ONFH, whereas BSP administration prevented ONFH development in 70% of prednisone-injected rats. We evaluated the constituents of BSP by HPLC fingerprinting. We also evaluated the clinical efficacy of BSP in a double-blind, randomized, controlled trial of 300 patients with ONFH. The response rate was found to be higher in the treatment group than in the control group, with a response rate of 82% in the treatment group. Treatment with BSP also significantly reduced pain, improved hip function, reduced lameness, and improved pathology by X-ray and MRI analysis, compared with patients who did not receive BSP. These results suggest that BSP treatment inhibits and reverses necrosis of the femoral head bone cells and cartilage cells to repair the femoral head, promote the repair of bone and cartilage diseases.

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