Oncotarget

Research Papers:

A genome-wide comprehensively analyses of long noncoding RNA profiling and metastasis associated lncRNAs in renal cell carcinoma

Xue Xu, Yongcan Xu, Chuanqin Shi, Baoyu Wang, Xiang Yu, Yanfen Zou and Tao Hu _

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Oncotarget. 2017; 8:87773-87781. https://doi.org/10.18632/oncotarget.21206

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Abstract

Xue Xu1,*, Yongcan Xu2,*, Chuanqin Shi1, Baoyu Wang1, Xiang Yu3, Yanfen Zou4 and Tao Hu1

1Department of Immunology, Binzhou Medical College, Yantai 264003, China

2Department of General Surgery, Huzhou Central Hospital, Huzhou 313000, China

3Department of General Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China

4Department of Obstetrics and Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China

*These authors have contributed equally to this work

Correspondence to:

Tao Hu, email: [email protected]

Yanfen Zou, email: [email protected]

Xiang Yu, email: [email protected]

Keywords: renal cell carcinoma, lncRNAs profiling, metastasis, prognosis, marker

Received: July 04, 2017    Accepted: August 04, 2017    Published: September 23, 2017

ABSTRACT

Recently, a growing number of studies have indicated that long noncoding RNAs (lncRNAs) are emerging as new critical regulators of tumorigenesis and prognostic markers in multiple cancers. However, the expression pattern of lncRNAs and their contributions in renal cell carcinoma (RCC) remains poorly understood. In this study, we performed a genome-wide comprehensively analysis of lncRNAs profiling and clinical relevance to provide valuable lncRNA candidates for the further study in RCC. RCC and non-tumor tissues RNA sequencing data, and microarray data were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), then, these data were annotated and analyzed to find dysregulated lncRNAs in RCC. We identified that hundreds of lncRNAs were differentially expressed in RCC tissues compared with normal tissues, and genomic variation analyses revealed that copy number amplification or deletion happened in some of these lncRNAs genome loci. Moreover, lots of lncRNAs expression levels are significantly associated RCC patients overall survival time, such as PVT1 and DUXAP8. Finally, we identified some novel metastasis associated lncRNAs in RCC (such as DUXAP8) by analyzing lncRNAs profiling in the RCC tissues from patients with metastasis compared with the primary RCC tissues without metastasis; knockdown of DUXAP8 could impair RCC cells invasive ability in vitro. Overall, our findings illuminate a lot of lncRNAs are aberrantly expressed in RCC that may offer useful resource for identification novel prognostic markers in this disease.


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