Long non-coding RNA LINC00959 predicts colorectal cancer patient prognosis and inhibits tumor progression
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Zhen-Qiang Sun1,*, Chen Chen1,*, Quan-Bo Zhou1, Jin-Bo Liu1, Shuai-Xi Yang1, Zhen Li1, Chun-Lin Ou2, Xian-Tao Sun1, Gui-Xian Wang1, Jun-Min Song1, Zhi-Yong Zhang1 and Wei-Tang Yuan1
1Department of Anorectal Surgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
2Cancer Research Institute, Central South University, Changsha 410008, China
*These authors have contributed equally to this work
Zhen-Qiang Sun, email: firstname.lastname@example.org
Wei-Tang Yuan, email: email@example.com
Jin-Bo Liu, email: firstname.lastname@example.org
Keywords: long non-coding RNA, LINC00959, colorectal cancer, epithelial-mesenchymal transition, biomarker
Received: April 25, 2017 Accepted: August 26, 2017 Published: September 21, 2017
Long non-coding RNAs (lncRNAs) are increasingly implicated in tumorigenesis and cancer progression. This study focused on the relationship between the lncRNA LINC00959 and colorectal cancer (CRC). We found that LINC00959 expression was lower in CRC tissues than normal colorectal mucosae. High LINC00959 expression was negatively associated with TNM stage, distant metastasis, and lymphatic metastasis, and correlated with a better prognosis in 87 CRC cases. In vitro, LINC00959 knockdown enhanced colon cancer cell proliferation, invasion, and migration; upregulated N-cadherin and vimentin; and downregulated E-cadherin and Caspase-3. LINC00959 overexpression produced the opposite effects. These data suggest that LINC00959 inhibits tumor cell invasion and migration by suppressing epithelial-mesenchymal transition and promotes apoptosis through Caspase-3. LINC00959 may be a tumor suppressor and useful prognostic biomarker in CRC.
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