Apoptosis in the aging liver

Hua-Hua Zhong, Shao-Jie Hu, Bo Yu, Sha-Sha Jiang, Jin Zhang, Dan Luo, Mei-Wen Yang, Wan-Ying Su, Ya-Lan Shao, Hao-Lin Deng, Fen-Fang Hong _ and Shu-Long Yang

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Oncotarget. 2017; 8:102640-102652. https://doi.org/10.18632/oncotarget.21123

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Hua-Hua Zhong1, Shao-Jie Hu1, Bo Yu1, Sha-Sha Jiang1, Jin Zhang1, Dan Luo1, Mei-Wen Yang1, Wan-Ying Su1, Ya-Lan Shao1, Hao-Lin Deng1, Fen-Fang Hong2 and Shu-Long Yang1

1Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China

2Department of Experimental Teaching Center, Nanchang University, Nanchang 330031, China

Correspondence to:

Fen-Fang Hong, email: [email protected]

Shu-Long Yang, email: [email protected]

Keywords: apoptosis, aging, liver, oxidative stress, genomic instability

Received: May 03, 2017     Accepted: August 15, 2017     Published: September 21, 2017


Various changes in the liver during aging can reduce hepatic function and promote liver injury. Aging is associated with high morbidity and a poor prognosis in patients with various liver diseases, including nonalcoholic fatty liver disease, hepatitis C and liver cancer, as well as with surgeries such as partial hepatectomy and liver transplantation. In addition, apoptosis increases with liver aging. Because apoptosis is involved in regeneration, fibrosis and cancer prevention during liver aging, and restoration of the appropriate level of apoptosis can alleviate the adverse effects of liver aging, it is important to understand the mechanisms underlying this process. Herein, we elaborate on the causes of apoptosis during liver aging, with a focus on oxidative stress, genomic instability, lipotoxicity, endoplasmic reticulum stress, dysregulation of nutrient sensing, and liver stem/progenitor cell activity.

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