Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study

Abstract

Background and aim: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients.

Results: One hundred and twenty-four patients were divided into three groups: 43 patients (34.68%) with sepsis, 39 patients (31.45%) with severe sepsis, and 42 patients (33.87%) with septic shock. The RIPK3 levels in the severe sepsis and septic shock groups were notably higher than those in sepsis group at various time points (all p < 0.05), and the RIPK3 levels had positive association with the Sequential Organ Failure Assessment (SOFA) score as well as procalcitonin (PCT) level (all p < 0.05). The RIPK3 level like the SOFA score and PCT level could be a prognostic biomarker of sepsis patients.

Materials and Methods: We prospectively recruited the eligible patients with sepsis, severe sepsis, or septic shock who were treated in our hospital from January 2014 to May 2016. The dynamic changes in infectious variables and blood plasma receptor interacting protein kinase 1 (RIPK1) and receptor interacting protein kinase 3 (RIPK3) levels were determined from measurements taken in a double-blinded fashion at 24, 48, 72, and 120 hours later.

Conclusions: These results suggested that dynamic monitoring of RIPK3 levels can contribute to the prediction of outcome of sepsis and might be of particular value in identifying patients who would benefit from specific treatments.