Oncotarget

Clinical Research Papers:

Association of genetic variations in the lipid regulatory pathway genes FBXW7 and SREBPs with coronary artery disease among Han Chinese and Uygur Chinese populations in Xinjiang, China

Asiya Abudesimu, Dilare Adi, Dilixiati Siti, Xiang Xie, Yi-Ning Yang, Xiao-Mei Li, Ying-Hong Wang, Yong-Tao Wang, Ya-Jie Meng, Fen Liu, Bang-Dang Chen, Xiang Ma, Zhen-Yan Fu and Yi-Tong Ma _

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Oncotarget. 2017; 8:88199-88210. https://doi.org/10.18632/oncotarget.21082

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Abstract

Asiya Abudesimu1,*, Dilare Adi1,*, Dilixiati Siti1,*, Xiang Xie1, Yi-Ning Yang1, Xiao-Mei Li1, Ying-Hong Wang1, Yong-Tao Wang1, Ya-Jie Meng1, Fen Liu2, Bang-Dang Chen2, Xiang Ma1, Zhen-Yan Fu1 and Yi-Tong Ma1

1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

2Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute of First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

*These authors contributed equally to this work

Correspondence to:

Yi-Tong Ma, email: [email protected], [email protected]

Zhen-Yan Fu, email: [email protected]

Xiang Ma, email: [email protected]

Keywords: SREBP family, FBXW7, coronary artery disease, case-control study

Received: May 26, 2017     Accepted: September 05, 2017     Published: September 19, 2017

ABSTRACT

Background: Hyperlipidemia is a major risk factor for coronary artery disease (CAD). The current study was designed to explore the possible correlation between single nucleotide polymorphisms (SNPs) in the lipid homeostasis regulatory genes F-box and WD repeat domain–containing 7 (FBXW7 ) and sterol regulatory element-binding proteins (SREBPs) with CAD among Han Chinese and Uygur Chinese populations in Xinjiang, China.

Results: In the Uygur Chinese population, rs9902941 in SREBP-1 and rs10033601 in FBXW7 were found to be associated with CAD in a recessive model (TT vs. CT + CC, P = 0.032; GG vs. AG + AA, P = 0.010, respectively), and rs7288536 in SREBP-2 was found to be associated with CAD in an additive model (CT vs. CC + TT, P = 0.045). The difference was statistically significant in the Uygur Chinese population after multivariate adjustments [Odds ratio (OR) = 1.803, 95% confidence interval (CI): 1.036~3.137, P = 0.037; OR = 1.628, 95% CI: 1.080~2.454, P = 0.020; OR = 1.368; and 95% CI: 1.018~1.837, P = 0.037, respectively]. There were also significant interactions between the above-mentioned models in the Uygur Chinese population. However, these relationships were not observed before or after multivariate adjustment in the Han Chinese population.

Materials and Methods: A total of 1,312 Han Chinese (650 CAD patients and 662 controls) and 834 Uygur Chinese (414 CAD patients and 420 controls) were enrolled in this case-control study. Three SNPs (rs9902941 in SREBP-1, rs7288536 in SREBP-2 and rs10033601 in FBXW7) were selected and genotyped using the improved multiplex ligase detection reaction (iMLDR) method.

Conclusions: The results of this study indicate that variations in the lipid regulatory pathway genes FBXW7 and SREBPs (rs9902941 in SREBP-1, rs7288536 in SREBP-2 and rs10033601 in FBXW7) are associated with CAD in the Uygur Chinese population in Xinjiang, China.


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