Research Papers:

The differential diagnostic value of serum homocysteine for white coat hypertension

Shitian Guo, Hui Lin, Sunlei Pan, Xiaoya Zhai and Liping Meng _

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Oncotarget. 2017; 8:101271-101283. https://doi.org/10.18632/oncotarget.21020

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Shitian Guo1, Hui Lin2,3, Sunlei Pan2,3, Xiaoya Zhai2 and Liping Meng2

1School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China

2Department of Cardiology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang, China

3The First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, China

Correspondence to:

Liping Meng, email: [email protected]

Keywords: white coat hypertension, Hcy, diagnosis, hypertension, ABPM

Received: July 22, 2017     Accepted: August 28, 2017     Published: September 18, 2017


Objective: To assess the value of serum homocysteine (Hcy) in differential diagnosis of white coat hypertension (WCH).

Results: In this retrospective study, serum Hcy levels were elevated in hypertensive patients (P < 0.001) compared to WCH patients. Serum Hcy levels were positively correlated with 24-h mean systolic blood pressure, r = 0.1378, P < 0.001. The results of the receiving operating characteristic (ROC) curve showed that the AUC value of Hcy was 0.80 (95% CI, 0.77–0.83), the cut-off value was 13.8 μmol/L, the sensitivity was 68.58% and the specificity 87.21%. In the prospective study, the AUC value of Hcy was 0.73 (95% CI: 0.67–0.78), higher than N - terminal pro - brain natriuretic peptide(NT-pro-BNP) (0.64, 95% CI:0.58–0.70) and cystatin C (Cys-C) (0.62, 95% CI:0.55–0.68). Hcy, NT-proBNP and Cys-C combined, provided a better indication of a differential diagnosis of WCH, than Hcy alone.

Materials and Methods: This investigation involved both a retrospective and a prospective study. Clinical data including blood pressure, age, sex, height, weight, BMI, smoking status, past history, and behavioral electrocardiogram of patients who had undergone 24-hour ambulatory blood pressure monitoring (ABPM) with elevated clinical blood pressure (BP) were recorded. Pearson correlation analysis was used to test the correlation between Hcy and BP. The ROC curve was used to analyze the value of measuring Hcy levels in differential diagnosis of WCH.

Conclusions: Serum Hcy was decreased in WCH patients and therefore could be a biomarker for differential diagnosis of WCH.

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