Research Papers:

Depression and its impact on health-related quality of life among Chinese inpatients with lung cancer

Wen Gu, Yan-Min Xu, Jun-Hong Zhu and Bao-Liang Zhong _

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:104806-104812. https://doi.org/10.18632/oncotarget.21001

Metrics: PDF 1715 views  |   HTML 2448 views  |   ?  


Wen Gu1, Yan-Min Xu2, Jun-Hong Zhu2 and Bao-Liang Zhong2

1Shenzhen Key Laboratory for Psychological Healthcare, Shenzhen Institute of Mental Health, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, Guangdong Province, China

2Affiliated Wuhan Mental Health Center, The Ninth Clinical School, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, China

Correspondence to:

Bao-Liang Zhong, email: [email protected]

Keywords: depression, lung cancer, quality of life, epidemiology

Received: August 01, 2017     Accepted: August 29, 2017     Published: September 18, 2017


Depression is of great concern for patients with cancer. A detailed epidemiological profile of depression in Chinese patients with lung cancer and whether depression impacts patients’ health-related quality of life (HRQOL) remain unknown. This study examined the prevalence and socio-demographic and clinical correlates of depression and its effect on HRQOL in Chinese inpatients with lung cancer of two large general hospitals. A total of 148 inpatients were consecutively recruited, and administered with a standardized questionnaire to collect socio-demographic and clinical data. Depression and HRQOL were assessed with the Hospital Anxiety and Depression Scale and World Health Organization QOL Scale Brief Version, respectively. As high as 43.2% Chinese inpatients with lung cancer had clinically significant depressive symptoms. Multiple logistic regression found that depression was significantly associated with moderate-to-severe pain (OR: 4.43), metastatic cancer (OR: 3.63), a short duration after cancer diagnosis (OR: 1.04), poor performance status (OR: 3.41), and small-cell cancer (OR: 4.52). Depressed patients had significantly poorer HRQOL than not depressed patients in terms of all four domains of HRQOL. After controlling for the potential confounding effects of socio-demographic and clinical factors with analysis of covariance, these group-differences in physical (F = 29.074, P < 0.001), psychological (F = 76.869, P < 0.001), social (F = 21.465, P < 0.001), and environmental (F = 27.685, P < 0.001) HRQOL remained statistically significant. Depression is prevalent in inpatients with lung cancer and independently associated with poor HRQOL. To address this serious issue, effective pain management, psycho-oncology services and, when necessary, psychiatric assessment and treatment, should be routinely provided in oncology departments of Chinese general hospitals.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 21001