Association between CYP2E1 genetic polymorphisms and urinary cancer risk: a meta-analysis

Zhiqing Fang, Yun Wu and Ning Zhang _

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Oncotarget. 2017; 8:86853-86864. https://doi.org/10.18632/oncotarget.20993

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Zhiqing Fang1, Yun Wu2 and Ning Zhang2

1Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China

2Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China

Correspondence to:

Ning Zhang, email: [email protected]

Keywords: cytochrome P4502E1, CYP2E1, polymorphism, urinary cancer, meta-analysis

Received: October 25, 2016     Accepted: August 29, 2017     Published: September 18, 2017


Objective: Studies investigating the contribution of Cytochrome P4502E1 (CYP2E1) polymorphisms to the etiology of urinary cancer draw inconsistent conclusions. Thus, we performed a meta-analysis to evaluate the association between CYP2E1 Rsa I/Pst I and Dra I polymorphisms and urinary cancer susceptibility.

Materials and Methods: Meta-analysis based on the eligible case-control studies that assess the association of CYP2E1 Rsa I/Pst I and Dra I polymorphisms with urinary cancer was conducted. Subgroup analyses based on ethnicity and cancer type were also carried out. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of the associations between the two polymorphisms. Funnel plot and Begg’s test were used for publication bias diagnosis.

Results: We found decreased urinary cancer risk among subjects carrying CYP2E1 RsaI/PstI c1c2 + c2c2 genotype and c2 allele (OR = 0.73, 95% CI = 0.68–0.79 and OR = 0.79, 95% CI = 0.74–0.85, respectively), with 3,301 cases and 3,786 controls from 14 studies. We also observed a significant difference in c1c2 + c2c2 vs. c1c1 and c2 vs. c1 among Asians (OR = 0.68, 95% CI = 0.60–0.78 and OR = 0.75, 95% CI = 0.66–0.85, respectively). However, the meta-analysis based on 5 eligible studies showed no significant association between CYP2E1 Dra I polymorphism and urinary cancer susceptibility in either dominant model or the allele model.

Conclusions: Our meta-analysis concluded that CYP2E1 Rsa I/Pst I polymorphism correlates with urinary cancers risk in Asian population; while CYP2E1 Dra I polymorphism might be not significantly associated with the urinary cancer risks. Large and well-designed studies are needed to confirm these results.

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