Survival rate variation with different histological subtypes of poor prognostic male anal squamous cell carcinoma: a population-based study

Zihao Wan; Zhihao Huang; Vikash Vikash; Kelash Rai; Sindhu Vikash; Liaobin Chen; Jingfeng Li

doi:10.18632/oncotarget.20969

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Research Papers:

Survival rate variation with different histological subtypes of poor prognostic male anal squamous cell carcinoma: a population-based study

Zihao Wan _, Zhihao Huang, Vikash Vikash, Kelash Rai, Sindhu Vikash, Liaobin Chen and Jingfeng Li

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Oncotarget. 2017; 8:84349-84359. https://doi.org/10.18632/oncotarget.20969

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Abstract

Zihao Wan1,*, Zhihao Huang2,*, Vikash Vikash3,*, Kelash Rai4, Sindhu Vikash5, Liaobin Chen1 and Jingfeng Li1

1Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China

2Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China

3Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China

4Department of Medicine, Ziauddin Hospital, Karachi, Sindh, Pakistan

5Department of Medicine, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Sindh, Pakistan

*These authors have contributed equally to this work

Correspondence to:

Zihao Wan, email: [email protected]

Liaobin Chen, email: [email protected]

Jingfeng Li, email: [email protected]

Keywords: anus squamous cell carcinoma, male, tumor subtype, retrospective cohort study, SEER database

Received: March 26, 2017 Accepted: August 17, 2017 Published: September 16, 2017

ABSTRACT

Background and objective: The prognosis of male anal squamous cell carcinoma (MASCC) and female anal squamous cell carcinoma (FASCC) is variable. The influence of tumor subtype on the survival rate and gender is poorly known. Our study is the largest population-based study and aims to outline the difference in survival between MASCC and FASCC patients.

Methods: A retrospective population-based study was performed to compare the disease-specific mortalities (DSMs) between genders related to the tumor subtypes. The Surveillance, Epidemiology, and End Results (SEER) program database was employed to obtain the data from January 1988 to December 2014.

Results: A total of 4,516, (3,249 males and 1,267 females), patients with anal squamous cell carcinomas (ASCC) were investigated. The 5-year DSMs were 24.18% and 18.08% for men and women, respectively. The univariate analysis of the male basaloid squamous cell carcinoma (BSCC) and cloacogenic carcinoma (CC) patients demonstrated higher DSMs (P <0.001). Moreover, in the multivariate analysis, BSCC and CC were associated with soaring DSMs in male patients (P < 0.05).

Conclusions: In the cohort of BSCC and CC patients, male patients demonstrated a considerable decrease in survival rate compared to females. A more precise classification of ASCC and individualized management for MASCC are warranted.

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Research Papers:

Survival rate variation with different histological subtypes of poor prognostic male anal squamous cell carcinoma: a population-based study

Abstract