TGFBR-IDH1-Cav1 axis promotes TGF-β signalling in cancer-associated fibroblast

Xiaodan Hou; Jieying Zhang; Yongbin Wang; Wujun Xiong; Jun Mi

doi:10.18632/oncotarget.20861

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

TGFBR-IDH1-Cav1 axis promotes TGF-β signalling in cancer-associated fibroblast

Xiaodan Hou, Jieying Zhang, Yongbin Wang, Wujun Xiong and Jun Mi _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:83962-83974. https://doi.org/10.18632/oncotarget.20861

Metrics: PDF 1927 views | HTML 2912 views | ?

Abstract

Xiaodan Hou1,3, Jieying Zhang1, Yongbin Wang1, Wujun Xiong2 and Jun Mi1

1Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2Shanghai East Hospital, Affiliated to Tongji University, Shanghai, China

3Center of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou Institute of Systems Medicine, Suzhou, China

Correspondence to:

Jun Mi, email: [email protected]

Wujun Xiong, email: [email protected]

Keywords: IDH1, TGFBR, TGF-β signalling, Cav1, alpha-ketoglutarate

Received: July 28, 2017 Accepted: August 23, 2017 Published: September 13, 2017

ABSTRACT

TGF-β signalling plays an important role in fibroblasts activation and tumour progression. Here, we report that the TGFBR-IDH1-Cav1 axis promotes TGF- β signalling in fibroblasts. Our data demonstrated that IDH1 was downregulated by TGF-β signalling in fibroblasts, and downregulation of IDH1 increased cellular concentration of α-ketoglutarate (α-KG) by accelerating glutamine metabolization. Interestingly, α-KG suppressed Cav1 expression through reducing the trimethylation of histone H3K4. Furthermore, Cav1 downregulation inhibited TGFBR protein degradation. In turn, the activated TGFBR promoted TGF-β signalling. These findings demonstrated that metabolic enzyme IDH1 regulates TGF-β signalling by feedback mechanism through α-KG and TGFBR-IDH1-Cav1 axis is important for TGF-β signalling.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 20861

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

TGFBR-IDH1-Cav1 axis promotes TGF-β signalling in cancer-associated fibroblast

Abstract