Oncotarget

Research Papers:

Association of ACYP2 and MPHOSPH6 genetic polymorphisms with the risk of hepatocellular carcinoma in chronic hepatitis B virus carriers

Yingai Zhang, Shunlan Wang, Xiaohong Wen, Shufang Zhang and Yijun Yang _

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Oncotarget. 2017; 8:86011-86019. https://doi.org/10.18632/oncotarget.20846

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Abstract

Yingai Zhang1,*, Shunlan Wang1,*, Xiaohong Wen1, Shufang Zhang1 and Yijun Yang2

1Central Laboratory, Haikou People’s Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, Hainan, China

2Department of Hepatobiliary Surgery, Haikou People’s Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, Hainan, China

*These authors have contributed equally to this work

Correspondence to:

Yijun Yang, email: dryyj@163.com

Shufang Zhang, email: haikouyiyuan@126.com

Keywords: hepatocellular carcinoma (HCC), hepatitis B virus (HBV), ACYP2, MPHOSPH6, association analysis

Received: June 01, 2017    Accepted: August 02, 2017    Published: September 12, 2017

ABSTRACT

Hepatocellular carcinoma (HCC) is the dominant histologic type of primary liver cancer, and hepatitis B virus (HBV) infection is one of the major causes of HCC in the chronic HBV. Our study was investigated the association between the polymorphisms of ACYP2 and MPHOSPH6 genes and the risk of HCC induced by HBV infection. A total of 490 subjects were divided into two groups: 248 HBV patients with HCC (Case group), and 242 HBV patients without HCC (Control group). Unconditional logistic regression analysis was used to evaluate the association. The genetic association analysis revealed variant of rs12621038 in ACYP2 gene had a significant association with increasing the risk of HBV-induced HCC based on the genotype, dominant and additive model (P<0.05). Moreover, our results also showed that minor allele “C” of rs3751862 was prevalent in cases than controls (P<0.05), and rs3751862 significantly increased the risk of HCC in chronic HBV carriers under genotype and dominant model (P<0.05). In addition, the haplotype “T-G-G” in MPHOSPH6 showed a harmful factor for the HBV-induced HCC (P<0.05). The results suggested that ACYP2 and MPHOSPH6 as the plausible candidate genes may predict the risk of HCC after chronic HBV infection in Chinese Han population, and further investigations in studies with a larger sample size and other races are needed to validate our findings. These data provide a theoretical foundation for future studies of this correlation between the polymorphisms of ACYP2 and MPHOSPH6 genes and the HCC in chronic HBV carriers.


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