Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma
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Qiwei Yang1,2,*, Ye Wang3,*, Xiuwu Pan1,2,*, Jianqing Ye1, Sishun Gan1, Fajun Qu1, Lu Chen4, Chuanmin Chu1, Yi Gao4 and Xingang Cui1
1Department of Urology, The Third Affiliated Hospital of Second Military Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai 201805, People’s Republic of China
2Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People’s Republic of China
3Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200082, People’s Republic of China
4Department of Urology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, People’s Republic of China
*These authors have contributed equally to this work
Xingang Cui, email: firstname.lastname@example.org
Yi Gao, email: email@example.com
Chuanmin Chu, email: firstname.lastname@example.org
Keywords: renal cell carcinoma, Wnt/β-catenin, Frizzled 8, proliferation, metastasis
Received: October 31, 2016 Accepted: August 08, 2017 Published: September 08, 2017
Recent reports have shown a rapid rise in the incidence of renal cell carcinoma (RCC), and Wnt (Wingless-related integration site) signaling pathway is important in RCC. Frizzled 8 (FZD8) is a member of Frizzled (FZD) receptor family which could activate canonical or non-canonical Wnt/β-catenin pathways. Nevertheless, the role of FZD8 in RCC is poorly investigated. The immunohistochemical analysis showed high expression of FZD8 in RCC tissues compared with peri-tumor tissues. FZD8 knockdown decreased the ability of proliferation and metastasis of RCC cells. Research revealed that the FZD8 regulated the transcription of Cyclin D1, c-Myc, and could promote the epithelial to mesenchymal transition (EMT) by mediating Vimentin and Snail through the Wnt/β-catenin signaling pathway. In addition, the results of our experiment revealed that FZD8 is involved in the regulation of non-canonical Wnt signaling pathway. These data suggested that the expression of FZD8 may play an important role in the proliferation and metastasis of RCC, and serve as a putative promising drug target for human RCC therapy.
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