Oncotarget

Research Papers:

Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma

Qiwei Yang, Ye Wang, Xiuwu Pan, Jianqing Ye, Sishun Gan, Fajun Qu, Lu Chen, Chuanmin Chu, Yi Gao and Xingang Cui _

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Oncotarget. 2017; 8:78989-79002. https://doi.org/10.18632/oncotarget.20742

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Abstract

Qiwei Yang1,2,*, Ye Wang3,*, Xiuwu Pan1,2,*, Jianqing Ye1, Sishun Gan1, Fajun Qu1, Lu Chen4, Chuanmin Chu1, Yi Gao4 and Xingang Cui1

1Department of Urology, The Third Affiliated Hospital of Second Military Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai 201805, People’s Republic of China

2Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People’s Republic of China

3Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200082, People’s Republic of China

4Department of Urology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Xingang Cui, email: cuixingangjiaoshou@yeah.net

Yi Gao, email: gaoyismmu@163.com

Chuanmin Chu, email: drchucm@163.com

Keywords: renal cell carcinoma, Wnt/β-catenin, Frizzled 8, proliferation, metastasis

Received: October 31, 2016     Accepted: August 08, 2017     Published: September 08, 2017

ABSTRACT

Recent reports have shown a rapid rise in the incidence of renal cell carcinoma (RCC), and Wnt (Wingless-related integration site) signaling pathway is important in RCC. Frizzled 8 (FZD8) is a member of Frizzled (FZD) receptor family which could activate canonical or non-canonical Wnt/β-catenin pathways. Nevertheless, the role of FZD8 in RCC is poorly investigated. The immunohistochemical analysis showed high expression of FZD8 in RCC tissues compared with peri-tumor tissues. FZD8 knockdown decreased the ability of proliferation and metastasis of RCC cells. Research revealed that the FZD8 regulated the transcription of Cyclin D1, c-Myc, and could promote the epithelial to mesenchymal transition (EMT) by mediating Vimentin and Snail through the Wnt/β-catenin signaling pathway. In addition, the results of our experiment revealed that FZD8 is involved in the regulation of non-canonical Wnt signaling pathway. These data suggested that the expression of FZD8 may play an important role in the proliferation and metastasis of RCC, and serve as a putative promising drug target for human RCC therapy.


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