Oncotarget

Research Papers:

Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota

Chen Diling _, Yang Xin, Zheng Chaoqun, Yang Jian, Tang Xiaocui, Chen Jun, Shuai Ou and Xie Yizhen

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Oncotarget. 2017; 8:85838-85857. https://doi.org/10.18632/oncotarget.20689

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Abstract

Chen Diling1,*, Yang Xin2,*, Zheng Chaoqun1, Yang Jian1, Tang Xiaocui1, Chen Jun3, Shuai Ou1,4 and Xie Yizhen1,4

1State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China

2Department of Pharmacy, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, China

3Departerment of Infertility and Sexual Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510631, China

4Guangdong Yuewei Edible Fungi Technology Co. Ltd, Guangzhou 510070, China

*These authors have contributed equally to this work

Correspondence to:

Chen Diling, email: diling1983@163.com

Xie Yizhen, email: xieyizhen@126.com

Keywords: anti-inflammatory, gut microbiota, Hericium erinaceus, immune-enhancing effect, inflammatory bowel disease

Received: May 14, 2017     Accepted: July 26, 2017     Published: September 06, 2017

ABSTRACT

Hericium erinaceus (HE), a traditional edible mushroom, is known as a medicine food homology to ameliorate gastrointestinal diseases. To investigate whether HE is clinically effective in alleviating inflammatory bowel disease (IBD), HE extracts (polysaccharide, alcoholic extracts and whole extracts were prepared using solvent extraction methods) were administrated for 2 weeks in rats with IBD induced by trinitro-benzene-sulfonic acid (TNBS) enema (150 mg/kg). Significant clinical and histological changes in IBD rats were identified, including damage activity, common morphous and tissue damage index scores in colonic mucosa and myeloperoxidase (MPO) activity. The damage activity, common morphous and tissue damage index scores in colonic mucosa (P <0.05) were improved, MPO activities were decreased. Inflammatory factors were also differentially expressed in colonic mucosa in IBD rats, including serum cytokines, Foxp3 and interleukin (IL)-10 were increased while NF-κB p65 and tumor necrosis factor (TNF)-α were decreased (P <0.05), and T cells were activated (P <0.05), especially in the alcohol extracts-treated group. We also found that the structure of gut microbiota of the H. erinaceus extracts-treated groups changed significantly by compared with the model group. Further studies revealed that the polysaccharides in HE extracts may play a prebiotic role, whereas the alcoholic extracts show bactericidin-like and immunomodulatory effects. Taken together, we demonstrated that H. erinaceus extracts could promote the growth of beneficial gut bacteria and improve the host immunity in vivo IBD model, which shows clinical potential in relieving IBD by regulating gut microbiota and immune system.


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