Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis
Metrics: PDF 3043 views | HTML 6355 views | ?
Zhanwei Zhao1, Quanxin Feng1, Zifang Yin2, Jianbo Shuang3, Bin Bai1, Pengfei Yu1, Min Guo1 and Qingchuan Zhao1
1Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi′an, China
2Department of Obstetrics, Northwestern Women and Children’s Hospital, Xi′an, China
3Department of General Surgery, Chinese PLA 323 Hospital, Xi′an, China
Qingchuan Zhao, email: [email protected]
Keywords: nutrition, red meat, processed meat, colorectal cancer, meta-analysis
Received: December 28, 2016 Accepted: June 09, 2017 Published: September 06, 2017
The associations between red and processed meat consumption and the risk of colorectal cancer types have not been conclusively defined. We performed a systematic review and meta-analysis to analyze these associations. We searched PubMed and EMBASE to identify studies published from inception through September 2016. Dose-response, subgroup and subtype analyses of colorectal cancer (colon cancer, proximal colon cancer, distal colon cancer and rectal cancer) were performed. We ultimately selected 60 eligible studies. Positive associations were observed for colorectal cancer in case-control studies (red meat, P<0.01; processed meat, P<0.01) and cohort studies (red meat, P<0.01; processed meat, P<0.01). However, subtype analyses yielded null results for distal colon cancer in case-control studies (P=0.41) and cohort studies (P=0.18) for red meat and null results for proximal colon cancer in case-control studies (P=0.13) and cohort studies (P=0.39) for processed meat. Additionally, although the results of case-control studies were positive (red meat, P<0.01; processed meat, P=0.04) for rectal cancer, there were no positive associations between red (P=0.34) and processed meat (P=0.06) consumption and the risk in cohort studies. In a systematic review and meta-analysis, we found consumption of red and processed meat was associated with the risk of overall colorectal cancer but not rectal cancer. Additionally, there were no associations between the consumption of red meat and distal colon cancer risk and between the consumption of processed meat and proximal colon cancer risk.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.