Oncotarget

Meta-Analysis:

Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

Zhanwei Zhao, Quanxin Feng, Zifang Yin, Jianbo Shuang, Bin Bai, Pengfei Yu, Min Guo and Qingchuan Zhao _

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Oncotarget. 2017; 8:83306-83314. https://doi.org/10.18632/oncotarget.20667

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Abstract

Zhanwei Zhao1, Quanxin Feng1, Zifang Yin2, Jianbo Shuang3, Bin Bai1, Pengfei Yu1, Min Guo1 and Qingchuan Zhao1

1Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi′an, China

2Department of Obstetrics, Northwestern Women and Children’s Hospital, Xi′an, China

3Department of General Surgery, Chinese PLA 323 Hospital, Xi′an, China

Correspondence to:

Qingchuan Zhao, email: [email protected]

Keywords: nutrition, red meat, processed meat, colorectal cancer, meta-analysis

Received: December 28, 2016     Accepted: June 09, 2017     Published: September 06, 2017

ABSTRACT

The associations between red and processed meat consumption and the risk of colorectal cancer types have not been conclusively defined. We performed a systematic review and meta-analysis to analyze these associations. We searched PubMed and EMBASE to identify studies published from inception through September 2016. Dose-response, subgroup and subtype analyses of colorectal cancer (colon cancer, proximal colon cancer, distal colon cancer and rectal cancer) were performed. We ultimately selected 60 eligible studies. Positive associations were observed for colorectal cancer in case-control studies (red meat, P<0.01; processed meat, P<0.01) and cohort studies (red meat, P<0.01; processed meat, P<0.01). However, subtype analyses yielded null results for distal colon cancer in case-control studies (P=0.41) and cohort studies (P=0.18) for red meat and null results for proximal colon cancer in case-control studies (P=0.13) and cohort studies (P=0.39) for processed meat. Additionally, although the results of case-control studies were positive (red meat, P<0.01; processed meat, P=0.04) for rectal cancer, there were no positive associations between red (P=0.34) and processed meat (P=0.06) consumption and the risk in cohort studies. In a systematic review and meta-analysis, we found consumption of red and processed meat was associated with the risk of overall colorectal cancer but not rectal cancer. Additionally, there were no associations between the consumption of red meat and distal colon cancer risk and between the consumption of processed meat and proximal colon cancer risk.


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