This article has been corrected. Correction in: Oncotarget. 2019; 10:3576.

The role of substance P in epilepsy and seizure disorders

Xue Feng Wang, Tong Tong Ge, Jie Fan, Wei Yang _ and Ran Ji Cui

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Oncotarget. 2017; 8:78225-78233. https://doi.org/10.18632/oncotarget.20606

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Xue Feng Wang1, Tong Tong Ge1, Jie Fan1, Wei Yang1 Bingjin Li1 and Ran Ji Cui1

1Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, People’s Republic of China

Correspondence to:

Wei Yang, email: [email protected]

Bingjin Li, email: [email protected]

Ran Ji Cui, email: [email protected]

Keywords: substance P, epilepsy, inflammation, neuron

Received: April 03, 2017     Accepted: August 17, 2017     Published: September 01, 2017


A range of evidence implicates the neuropeptide substance P (SP), a member of the tachykinin family, in emotional behavior, anxiety, pain, and inflammation. Recently, SP has been implicated in susceptibility to seizures, for which a potential proconvulsant role was indicated. Indeed, antagonists of a specific SP receptor, neurokinin-1 receptor, were found to attenuate kainic acid (KA)-induced seizure activity. However, detailed mechanisms of SP regulation in epilepsy remain obscure. In this review, we summarize the present literature to expound the role of SP in epilepsy, and provide hypotheses for potential mechanisms.

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