Clinical Research Papers:

Preoperative radiotherapy for patients with rectal cancer: a risk factor for non-reversal of ileostomy caused by stenosis or stiffness proximal to colorectal anastomosis

Hongbo Zhu, Bingjun Bai, Lina Shan, Xiaowei Wang, Min Chen, Weifang Mao and Xuefeng Huang _

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Oncotarget. 2017; 8:100746-100753. https://doi.org/10.18632/oncotarget.20602

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Hongbo Zhu1,2, Bingjun Bai1,2, Lina Shan1,2, Xiaowei Wang1, Min Chen1, Weifang Mao1 and Xuefeng Huang1

1Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

2Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China

Correspondence to:

Xuefeng Huang, email: [email protected]

Keywords: rectal neoplasms, radiotherapy, anastomotic stenosis, permanent stoma, ileostomy

Received: June 14, 2017     Accepted: July 26, 2017     Published: September 01, 2017


The influence of radiotherapy on permanent stoma and the bowel proximal to anastomosis was not well investigated. The current study aimed to analyze the effect of preoperative radiotherapy on colorectal anastomosis and incidence of non-reversal ileostomy. A total of 184 eligible patients with rectal cancer undergoing loop ileostomy were included. Patients were well selected by excluding some confounding factors and divided into two groups according to whether they received preoperative radiotherapy.

Patients with preoperative radiotherapy had higher incidence of non-reversal stoma (12.8%, P = 0.004) and stenosis or stiffness around anastomosis (21.1%, P < 0.01) including 13 patients with stenosis or stiffness proximal to anastomosis. Stenosis proximal to anastomosis was different from anastomotic stricture caused by surgery and could be described by imaging findings. Preoperative radiotherapy prolonged the interval to closure (P = 0.008) and was defined as a significant risk factor for permanent stoma (HR, 0.627; 95% CI, 0.405–0.973; P = 0.04) by multivariate Cox regression analysis. In conclusion, Preoperative radiotherapy increased incidence of non-reversal ileostomy and stenosis or stiffness proximal to anastomosis in rectal cancer patients with radical resection and diverting ileostomy.

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