Oncotarget

Research Papers:

Association of serum cystatin C levels with mortality in patients with acute type A aortic dissection

Wei-Zhong Feng, Jun-Qing Zhou _, Guang-Mao Yu, Yong Zeng and Peng Xu

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Oncotarget. 2017; 8:101103-101111. https://doi.org/10.18632/oncotarget.20593

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Abstract

Wei-Zhong Feng1, Jun-Qing Zhou1, Guang-Mao Yu1, Yong Zeng1 and Peng Xu1

1Department of Cardiothoracic Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China

Correspondence to:

Jun-Qing Zhou, email: jun_qingzhou@sina.com

Guang-Mao Yu, email: guangmaoyu0@outlook.com

Keywords: acute type A aortic dissection, cystatin C, high sensitive C-reactive protein, mortality, prognosis

Received: June 15, 2017     Accepted: July 26, 2017     Published: August 30, 2017

ABSTRACT

Increased serum cystatin C levels are related to the prognosis of cardiovascular diseases. This study aims to investigate the effect of admission serum cystatin C levels on short- and long-term mortality in patients with acute type A aortic dissection (ATAAD). From 2010 to 2014, 136 consecutive patients with ATAAD were enrolled and followed up. Clinical data and laboratory assays including were measured. During a median follow-up of 198.7 days, the short-term mortality (30-days) was 20.6%, whereas the long-term death rate was 10.2%. We identified that the expression of cystatin C and high-sensitivity C-reactive protein (hs-CRP) in the dying patients was higher than in the surviving patients (P < 0.01). Hs-CRP (HR = 1.41, 95% CI: 1.03–2.59, P = 0.037) was an independent risk factor of short-term death determined by univariate and multivariate Cox analyses. No impact of cystatin C was observed on the short-term mortality. For long-term mortality, cystatin C (HR = 1.49, 95% CI: 1.10–7.36, P = 0.013) was identified as an independent predictor at above the cut-off value ≥ 1.10 mg/L. ROC analysis showed the AUC values of cystatin C and hs-CRP were 0.772 (95% CI, 0.692–0.839) and 0.640 (95% CI, 0.574–0.739), respectively, in the prediction of long-term death. The combined AUC value of cystatin C and hs-CRP was 0.883 (95% CI, 0.826–0.935; P < 0.01). Taken together, high cystatin C levels (≥ 1.10 mg/L) on admission are independently associated with the long-term mortality in patients with ATAAD.


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