Improving anti-melanoma effect of curcumin by biodegradable nanoparticles

Bilan Wang; Xiaoxiao Liu; Yan Teng; Ting Yu; Junli Chen; Yuzhu Hu; Na Liu; Lingli Zhang; Yangmei Shen

doi:10.18632/oncotarget.20585

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Research Papers:

Improving anti-melanoma effect of curcumin by biodegradable nanoparticles

Bilan Wang, Xiaoxiao Liu, Yan Teng, Ting Yu, Junli Chen, Yuzhu Hu, Na Liu, Lingli Zhang and Yangmei Shen _

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Oncotarget. 2017; 8:108624-108642. https://doi.org/10.18632/oncotarget.20585

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Abstract

Bilan Wang1,3,4,6, Xiaoxiao Liu5,6, Yan Teng7, Ting Yu6, Junli Chen7, Yuzhu Hu6, Na Liu7,8, Lingli Zhang1,3,4,6 and Yangmei Shen2,3

1Department of Pharmacy, West China Second university Hospital, Sichuan University, Chengdu, PR China

2Department of Pathology, West China Second university Hospital, Sichuan University, Chengdu, PR China

3Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second university Hospital, Sichuan University, Chengdu, PR China

4Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, PR China

5Department of Radiation Oncolo, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China

6Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu, PR China

7Research Unit of Infection and Immunity, Department of Pathophysiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, China

8Puyang Medical College, Puyang, Henan, China

Correspondence to:

Yangmei Shen, email: [email protected]

Keywords: melanoma; curcumin; micelles; cell apoptosis

Received: April 25, 2017 Accepted: August 06, 2017 Published: August 24, 2017

ABSTRACT

Melanoma is known as the most common malignant cutaneous cancer. Curcumin, a natural component, has been shown to have various activities such as anti-oxidant, anti-septic, anti-inflammatory, anti-biotic, anti-amyloid and anti-thrombosis. However, there is a greatest obstacle in the administration of curcumin due to its hydrophobicity and low oral bioavailability. In this study, we formulated curcumin-loaded MPEG-PLA (Curcumin/MPEG-PLA) micelles aiming to improve its solubility in aqueous solution and investigated anti-tumor effect on melanoma in vitro and in vivo. The spherical curcumin/MPEG-PLA micelles were completely dispersed in normal saline and could release curcumin in a sustained manner in vitro. In addition, we demonstrated that curcumin/MPEG-PLA micelles had stronger cytotoxicity and induced a higher percentage of apoptosis in B16 and A375 cancer cells than free curcumin in vitro. The immunohistochemical study revealed that curcumin/MPEG-PLA micelles induced more melanoma cell apoptosis than free curcumin and inhibited neovascularization in tumor tissues. In conclusion, the curcumin/MPEG-PLA micelles have potential clinical application for melanoma.

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Research Papers:

Improving anti-melanoma effect of curcumin by biodegradable nanoparticles

Abstract