Prognostic value of lymphocyte-to-monocyte ratio among Asian lung cancer patients: a systematic review and meta-analysis

Wen Li, Guangzhi Ma, Qiang Wu, Yunfu Deng, Ya Liu and Jing Wang _

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Oncotarget. 2017; 8:110606-110613. https://doi.org/10.18632/oncotarget.20574

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Wen Li1,2,*, Guangzhi Ma2,3,*, Qiang Wu2,*, Yunfu Deng2, Ya Liu1 and Jing Wang1

1Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, P.R. China

2Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, P.R. China

3Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, P.R. China

*These authors contributed equally to this work

Correspondence to:

Jing Wang, email: [email protected]

Keywords: lymphocyte to monocyte ratio (LMR), lung cancer, prognosis, meta-analysis

Received: July 08, 2017     Accepted: August 04, 2017     Published: August 28, 2017


Purpose: Numerous studies have reported the prognostic significance of lymphocyte-to-monocyte ratio (LMR) in malignancies, but its prognostic value among lung cancer remains controversial. This meta-analysis aimed to explore the prognostic significance of LMR in lung cancer patients.

Results: Eight studies including 3954 patients were included in this meta-analysis. Pooled results indicated that low LMR was significantly associated with poorer progression-free survival (hazard ratio (HR): 1.431, 95% confidence interval (CI): 1.294–1.582, p < 0.001) and overall survival (OS) (HR: 1.651, 95% CI: 1.306–2.086, p < 0.001), compared with high LMR. Similar results were observed in subgroups regardless of treatment, LMR cut-off value, or districts. However, no significant correlation between the LMR and OS was observed in the small cell lung cancer (SCLC) subgroup (HR = 1.262, 95% CI: 0.864–1.841, p = 0.229).

Materials and Methods: Identified literatures were extracted and retrieved from PubMed, Embase, Web of Science, and the Cochrane Library databases; All eligible studies focused on the association between LMR and the prognosis of lung cancer.

Conclusions: Low LMR is associated with poor outcomes among lung cancer patients. Further studies are needed to discuss the correlation between LMR and lung cancer prognosis.

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