Oncotarget

Research Papers:

Sirtuin 7: a new marker of aggressiveness in prostate cancer

Romain Haider, Fabienne Massa, Lisa Kaminski, Stephan Clavel, Zied Djabari, Guillaume Robert, Kathiane Laurent, Jean-François Michiels, Matthieu Durand, Jean-Ehrland Ricci, Jean-François Tanti, Frédéric Bost _ and Damien Ambrosetti

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Oncotarget. 2017; 8:77309-77316. https://doi.org/10.18632/oncotarget.20468

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Abstract

Romain Haider1,2,*, Fabienne Massa1,*, Lisa Kaminski1, Stephan Clavel1, Zied Djabari1, Guillaume Robert1, Kathiane Laurent1, Jean-François Michiels3, Matthieu Durand2, Jean-Ehrland Ricci1, Jean-François Tanti1, Frédéric Bost1,** and Damien Ambrosetti3,**

1Université Côte d’Azur, C3M-Inserm U1065, Nice, France

2Urology Department, CHU Nice, Nice, France

3Pathology Department, CHU Nice, Nice, France

*Co-first authors

**Co-last authors

Correspondence to:

Frédéric Bost, email: [email protected]

Keywords: prostate cancer, sirtuins, metastasis, metabolism, cell migration

Received: March 22, 2017     Accepted: July 25, 2017     Published: August 24, 2017

ABSTRACT

Predictive biomarkers for advanced prostate cancer (PCa) are still missing. The sirtuin 7 (SIRT7) has been linked to tumorogenesis but its role in prostate cancer is poorly documented. To determine if SIRT7 can be a biomarker for aggressive prostate cancer and plays a role in PCa aggressiveness. We analyzed the expression of SIRT7 by immunohistochemistry in 57 patients comparing healthy with adjacent cancer tissue. SIRT7 levels were significantly elevated in tumors and its expression was positively associated with the grade. We also demonstrated that the knock down of SIRT7 decreased the migration of DU145 and PC3 cells (two androgen-independent prostate cancer cell lines) whereas the overexpression of the native protein but not the mutated form increased the cell migration and the invasion of the poorly aggressive prostate cancer cell line LNCaP. Finally, we also showed that SIRT7 overexpression induced the resistance to docetaxel. Our results demonstrate that SIRT7 promotes prostate cancer cell aggressiveness and chemoresistance and suggest that SIRT7 is a good predictive biomarker of PCa aggressiveness.


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