Research Papers:

A retrospective study of elevated post-operative parathormone in primary hyperparathyroid patients

Shaobo Cao, Ya Hu, Yiming Zhao, Zhe Su, Zhiyan Xu, Xiang Gao, Quan Liao _ and Yupei Zhao

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Oncotarget. 2017; 8:101158-101164. https://doi.org/10.18632/oncotarget.20416

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Shaobo Cao1,*, Ya Hu1,*, Yiming Zhao1, Zhe Su1, Zhiyan Xu1, Xiang Gao1, Quan Liao1 and Yupei Zhao1

1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China

*These authors have contributed equally to this work

Correspondence to:

Quan Liao, email: [email protected]

Yupei Zhao, email: [email protected]

Keywords: primary hyperparathyroidism; normocalcemic parathormone elevation; parathyroidectomy; risk factors; recurrent hyperparathyroidism

Received: February 13, 2017    Accepted: June 16, 2017    Published: August 24, 2017


We retrospectively analyzed the relationship between normocalcemic parathormone elevation (NPE) and recurrence of primary hyperparathyroidism (pHPT) after surgery, as well as the risk factors of NPE. Out of 309 patients with pHPT that underwent parathyroidectomy. Six months after surgery, 75 patients exhibited NPE with high preoperative serum levels of alkaline phosphatase, calcium and intact parathyroid hormone (iPTH), postoperative day 1 iPTH, and large parathyroid volume. 15 exhibited NPE at 2 years after surgery with low serum vitamin D levels. Postoperative serum iPTH levels gradually normalized in most patients. Multivariate analysis showed that male patients were at greater risk for postoperative NPE (p<0.05). Only 3 of 309 patients showed recurrence during the follow-up period. NPE may not predict recurrent hyperparathyroidism or incomplete parathyroidectomy for benign parathyroid lesions. Postoperative NPE thus appears to be a response to severe hyperparathyroidism and vitamin D deficiency.

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