Oncotarget

Research Papers:

Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer

Rui-Yun Chen, Ying-Chun Lin, Shang-Wen Chen, Tze-Yi Lin, Te-Chun Hsieh, Kuo-Yang Yen, Ji-An Liang, Shih-Neng Yang, Yao-Ching Wang, Ya-Huey Chen, Shu-Fen Chiang and Chia-Hung Kao _

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Oncotarget. 2017; 8:72342-72351. https://doi.org/10.18632/oncotarget.20374

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Abstract

Rui-Yun Chen1,*, Ying-Chun Lin2,3,*, Shang-Wen Chen2,4,5,6, Tze-Yi Lin1, Te-Chun Hsieh7,8, Kuo-Yang Yen7,8, Ji-An Liang2,6, Shih-Neng Yang2,8, Yao-Ching Wang2, Ya-Huey Chen9,10, Shu-Fen Chiang11 and Chia-Hung Kao6,7,12

1Department of Pathology, China Medical University Hospital, Taichung, Taiwan

2Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan

3The Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan

4School of Medicine, China Medical University, Taichung, Taiwan

5School of Medicine, Taipei Medical University, Taipei, Taiwan

6Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

7Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan

8Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

9Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan

10Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan

11Cancer Center, China Medical University Hospital, Taichung, Taiwan

12Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan

*Authors contributed equally to this work

Correspondence to:

Chia-Hung Kao, email: [email protected]

Shang-Wen Chen, email: [email protected]

Keywords: squamous cell carcinoma, p16-negative pharyngeal cancer, biomarker, positron emission tomography–computed tomography, gross tumor volume

Received: May 07, 2017     Accepted: August 07, 2017     Published: August 21, 2017

ABSTRACT

Background: This study determined the prognostic effects of immunohistochemical biomarkers and volumetric parameters predicting radiotherapy-based treatment in patients with p16-negative squamous cell carcinoma of the oropharynx or hypopharynx.

Results: VEGF immunoreactivity > 2 and GLUT1 overexpression were prognostic factors for lower cause-specific survival. Moreover, both factors were associated with lower disease-free survival. The predictors of lower primary relapse-free survival were VEGF immunoreactivity > 2 and CT-based gross tumor volume > 16 mL.

Materials and Methods: Immunohistochemical biomarkers in pretreatment biopsy specimens from 60 patients with p16-negative cancer were analyzed using tissue microarrays. Computed tomography (CT)-based and biological tumor volumes were retrieved through fluorodeoxyglucose positron emission tomography-CT. Correlations of cause-specific, disease-free, and primary relapse-free survival with volumetric parameters and the immunohistochemical biomarker score were investigated.

Conclusions: For patients with p16-negative pharyngeal cancer receiving radiotherapy, treatment outcomes can be stratified by VEGF and GLUT1 expression and CT-based gross tumor volume.


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