Oncotarget

Research Papers:

Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients

Xuan Cheng, Nan-Chang Xie, Hong-Liang Xu, Chen Chen and Ya-Jun Lian _

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Oncotarget. 2017; 8:77086-77095. https://doi.org/10.18632/oncotarget.20356

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Abstract

Xuan Cheng1, Nan-Chang Xie1, Hong-Liang Xu1, Chen Chen1 and Ya-Jun Lian1

1Department of Neurology, The first affiliated hospital of Zhengzhou University, Zhengzhou, Henan province, P.R. China

Correspondence to:

Ya-Jun Lian, email: [email protected]

Keywords: aspirin resistance, infarct volume, stroke severity, diffusion-weighted imaging

Received: May 16, 2017    Accepted: June 30, 2017    Published: August 18, 2017

ABSTRACT

To explore the correlation of aspirin resistance (AR) with clinical stroke severity and infarct volume using diffusion-weighted imaging (DWI) in 224 Chinese ischemic stroke patients who were taking aspirin before stroke onset. In those patients, the median age was 64 years (IQR, 56-75 years), and males accounting for 54.9%(123)of the total subjects. Fifty of 224 enrolled patients (22.3%; 95% confidence interval (CI), 16.9% to 27.7%) showed AR. In the median regression model, significant increase was estimated in NIHSS score of 0.04 point for every 1-point increase in aspirin reaction units (ARU) (95% CI, 0.02 to 0.06; P<0.001). Diffusion-weighted MRI (DWI)-measured infarct volume were significantly higher in patients with AR as compared with those with AS [13.21 (interquartile ranges [IQR], 8.51-23.88) vs.4.26 (IQR, 1.74-11.62); P<0.001). Furthermore, a statistically significant increase was also measured in NIHSS score of 0.05 point for every 1-point increase in ARU in the median regression model (95% CI, 0.03 to 0.08; P<0.001). The median DWI infarct volume was significantly larger in the highest ARU quartile when compared to that in the low 3 quartiles (P<0.001). In conclusion, stroke patients with AR indicated higher risk of severe strokes and large infarcts compared to patients in the aspirin-sensitive group.


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