Oncotarget

Meta-Analysis:

Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis

Zhiqiang Chen, Yi Zheng, Guanghai Ji, Xinxin Liu, Peng Li, Lei Cai, Yulin Guo and Jian Yang _

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Oncotarget. 2017; 8:77975-77989. https://doi.org/10.18632/oncotarget.20316

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Abstract

Zhiqiang Chen1,2,*, Yi Zheng2,*, Guanghai Ji2, Xinxin Liu3, Peng Li2, Lei Cai2, Yulin Guo2 and Jian Yang1

1Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China

2Radiology Department of The General Hospital, Ningxia Medical University, Yinchuan 750004, Ningxia, China

3Department of Diagnostic Imaging, Honghui Hospital, Health Science Center of Xi'an Jiaotong University, Xi'an 750004, Shaanxi, China

*These authors contributed equally to this work

Correspondence to:

Jian Yang, email: [email protected]

Keywords: diagnostic imaging, diagnostic techniques, early detection of cancer, magnetic resonance imaging, male

Received: March 03, 2017     Accepted: August 04, 2017     Published: August 17, 2017

ABSTRACT

The goals of this meta-analysis were to assess the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with prostate carcinoma (PCa) and to explore the risk profiles with the highest benefit. Systematic electronic searched were conducted in database. We used patient-based and biopsy-based pooled weighted estimates of the sensitivity, specificity, and a summary receiver operating characteristic (SROC) curve for assessing the diagnostic performance of DCE. We performed direct and indirect comparisons of DCE and other methods of imaging. A total of 26 articles met the inclusion criteria for the analysis. DCE-MRI pooled sensitivity was 0.53 (95% CI 0.39 to 0.67), with a specificity of 0.88 (95% CI 0.83 to 0.92) on whole gland. The peripheral zone pooled sensitivity was 0.70 (95% CI 0.46 to 0.86), with a specificity of 0.88 (95% CI 0.76 to 0.94). Compared with T2-weighted imaging (T2WI), DCE was statistically superior to T2. In conclusion, DCE had relatively high specificity in detecting PCa but relatively low sensitivity as a complementary functional method. DCE-MRI might help clinicians exclude cases of normal tissue and serve as an adjunct to conventional imaging when seeking to identify tumor foci in patients with PCa.


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