Oncotarget

Research Papers:

TCF7L2 rs290481 T>C polymorphism is associated with an increased risk of type 2 diabetes mellitus and fasting plasma glucose level

Li Zhu, Zhiqiang Xie, Jianping Lu, Qiu Hao, Mingqiang Kang, Shuchen Chen, Weifeng Tang, Hao Ding, Yu Chen, Chao Liu and Haojie Wu _

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Oncotarget. 2017; 8:77000-77008. https://doi.org/10.18632/oncotarget.20300

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Abstract

Li Zhu1,*, Zhiqiang Xie2,*, Jianping Lu3, Qiu Hao4, Mingqiang Kang5, Shuchen Chen5, Weifeng Tang5, Hao Ding6, Yu Chen7, Chao Liu8 and Haojie Wu9

1Department of Nephrology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China

2Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China

3Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China

4Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, China

5Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China

6Department of Respiratory Disease, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China

7Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China

8Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China

9Department of Endocrinology, Zhongshan Hospital Xiamen University, Xiamen, Fujian Province, China

*These authors have contributed equally to this work

Correspondence to:

Haojie Wu, email: [email protected]

Keywords: TCF7L2, polymorphism, type 2 diabetes mellitus, risk

Received: April 19, 2017    Accepted: June 20, 2017    Published: August 16, 2017

ABSTRACT

Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene may be key agents in the etiology of type 2 diabetes mellitus (T2DM). In the present case-control study, we aimed to assess the possible relationship of TCF7L2 polymorphisms with T2DM and determine the effect of TCF7L2 polymorphisms on the level of fasting plasma glucose (FPG) in Eastern Chinese Han subjects. The TCF7L2 rs7903146C>T and rs290481 T>C polymorphisms were genotyped by SNPscan genotyping assays in 502 subjects with T2DM and 782 non-diabetic controls. After adjusting for age, gender, drinking, smoking and body mass index (BMI), the association of TCF7L2 rs7903146C>T and rs290481 T>C polymorphisms with T2DM was determined. We found that TCF7L2 rs290481 T>C polymorphism increased the susceptibility of T2DM in the overall comparison. In subgroup analyses by age, sex, BMI, alcohol use and smoking status, a significantly increased risk of T2DM was also found in female, older subject and never drinking and BMI < 24 kg/m2 subgroups. The relationship of TCF7L2 rs290481 T>C polymorphism with the biochemistry characteristics in controls was also assessed. We found that TCF7L2 rs290481 T>C polymorphism significantly increased the level of FPG in controls. Our findings suggest that TCF7L2 rs290481 T>C polymorphism is associated with T2DM in Eastern Chinese Han population and links to variations in FPG level. In addition, these relationships are more pronounced in female, older subject and never drinking and BMI < 24 kg/m2 subgroups. A comprehensive fine-mapping study with functional investigation is needed to confirm or refute these potential correlations.


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