Research Papers:

Toll-like receptor 5 gene polymorphism is associated with breast cancer susceptibility

Chen Shuang, Yuan Weiguang, Fu Zhenkun, Huang Yike, Yang Jiankun, Xue Jing, Liu Xinghan, Li Yue _ and Li Dalin

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Oncotarget. 2017; 8:88622-88629. https://doi.org/10.18632/oncotarget.20242

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Chen Shuang1,2, Yuan Weiguang3, Fu Zhenkun1, Huang Yike1, Yang Jiankun1, Xue Jing1, Liu Xinghan4, Li Yue5 and Li Dalin6

1Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin Medical University and Heilongjiang Academy of Medical Sciences, Harbin, China

2Department of Immunology, Harbin Medical University, Harbin, China

3Department of Cancer Immunology, Cancer Institute of Harbin Medical University, Department of Cancer Immunology, Heilongjiang Academy of Medical Sciences, Harbin, China

4Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China

5Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China

6Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China

Correspondence to:

Li Yue, email: [email protected]

Li Dalin, email: [email protected]

Keywords: breast cancer, TLR5, SNP, clinical features

Abbreviation: IDC, infiltrative ductal carcinoma

Received: December 01, 2016    Accepted: July 17, 2017    Published: August 14, 2017


Toll-like receptor 5 (TLR5) plays a fundamental role in immune responses. Recent findings suggest the TLR5 expression level affects cancer progression and development. In the present study, our examination of 256 breast carcinomas specimens revealed that TLR5 is overexpressed in breast carcinomas, and that TLR5 overexpression correlated with lymph node metastasis and cancer grade (p<0.01). In a case-control study, we also analyzed associations between TLR5 single nucleotide polymorphisms (SNPs) and breast cancer risk. Compared were 516 Chinese Han women diagnosed mainly with infiltrative ductal carcinoma and 520 age-matched healthy controls. The nonsense SNP rs5744168 causes truncation of the TLR5 transmembrane signaling domain and was associated with breast cancer risk (p<0.05). However, no statistical association was detected between SNP rs5744168 and any of the clinical parameters tested. Our findings thus indicate that TLR5 SNP rs5744168 is associated with sporadic breast cancer occurrence.

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