Oncotarget

Clinical Research Papers:

Persistence of type-specific human papillomavirus infection among Daqing City women in China with normal cytology: a pilot prospective study

Ni Li, Dong Hang, Lin Yang, Xiaoshuang Feng, Zhangyan Lyu, Shuanghua Xie, Jing Zhou, Lingying Wu, Xiaoguang Li, Nan Li, Min Cheng, Kai Zhang, Zhihui Zhang, Hong Cui, Jian Yin, Zhibin Hu, Hongbing Shen and Min Dai _

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Oncotarget. 2017; 8:81455-81461. https://doi.org/10.18632/oncotarget.20188

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Abstract

Ni Li1,*, Dong Hang2,*, Lin Yang1,3, Xiaoshuang Feng1, Zhangyan Lyu1, Shuanghua Xie1, Jing Zhou2, Lingying Wu4, Xiaoguang Li4, Nan Li4, Min Cheng4, Kai Zhang5, Zhihui Zhang6, Hong Cui1, Jian Yin1,2, Zhibin Hu2, Hongbing Shen2 and Min Dai1

1Program Office for Cancer Screening in Urban China, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

2Department of Epidemiology and Biostatistics, Collaborative Innovation Center of Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, China

3Department of Hospital Infection Control, Beijing Jishuitan Hospital, Fourth Medical College of Peking University, Beijing, China

4Department of Gynecology Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

5Department of Cancer Prevention, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

6Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

*Authors contributed equally to this work

Correspondence to:

Min Dai, email: daimin2002@hotmail.com

Ni Li, email: lini1240@hotmail.com

Keywords: human papillomavirus, type-specific persistence, cervical cancer, prospective study

Received: October 13, 2016     Accepted: August 06, 2017     Published: August 11, 2017

ABSTRACT

Persistence of high-risk human papillomavirus (HPV) represents the necessary cause of cervical cancer. Researching natural history of HPV infection is important to identify high-risk population of cervical cancer. Since HPV infection is population-specific, the findings in western populations could not be simply extended to Chinese and Asian females. This study investigated the type-specific persistence of HPV and related factors among Daqing City women in China. A total of 1759 women aged 18–80 years were enrolled at baseline. Cervical cell specimens were collected for cytological examination and HPV detection. HPV-positive individuals with normal cytology were followed up after 12 months. The results showed that HPV prevalence was 8.64% at baseline, of which 85 HPV-positive cases with normal cytology were followed up. The one-year type-specific persistence of HPV and high-risk types were 34.12% (29/85) and 34.25% (25/73), respectively. The top three high-risk types were HPV16 (7/17, 41.18%), HPV18 (5/8, 62.50%) and HPV58 (7/15, 46.67%). Age > 50 years was significantly associated with a higher risk of HPV persistence compared to ≤ 50 (OR = 2.73; 95% CI: 1.07, 6.93). In conclusion, approximately one-third of Daqing City women with HPV infection had at least one-year viral persistence, most of which were high-risk types. Older age represents a risk factor of HPV persistence.


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