The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis

Chengshuo Zhang, Baomin Chen, Ao Jiao, Feng Li, Bowen Wang, Ning Sun and Jialin Zhang _

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Oncotarget. 2017; 8:86843-86852. https://doi.org/10.18632/oncotarget.20045

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Chengshuo Zhang1, Baomin Chen1, Ao Jiao1, Feng Li1, Bowen Wang1, Ning Sun1 and Jialin Zhang1

1Hepatobiliary Surgery Department and Unit of Organ Transplantation, First Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China

Correspondence to:

Jialin Zhang, email: [email protected]

Keywords: hepatectomy, immunonutrition, ω-3 fatty acids, randomized controlled trials, meta-analysis

Received: May 30, 2017     Accepted: July 26, 2017     Published: August 08, 2017


Perioperative immunonutrition in liver resection remains doubtful. A systematic review and meta-analysis was conducted to compare postoperative outcomes between patients undergoing hepatectomy who received perioperative immunonutrition and those who did not.A PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Knowledge database search was performed to retrieve all of the randomized controlled trials (RCTs) evaluating the value of perioperative immunonutrition in patients undergoing hepatectomy until the end of September 2016. Data extraction and quality assessment of RCTs were performed in accordance with PRISMA guidelines. The quality of evidence for each postoperative outcome was assessed using the GRADEpro analysis. A random-effects model was used to conduct a meta-analysis with RevMan 5.3.5 software. Eight RCTs including 805 patients (402 with and 403 without immunonutrition) were identified. Immunonutrition, mainly ω-3 fatty acids, significantly reduced the incidence of postoperative total complications (risk ratio [RR] = 0.59; 95% confidence interval [CI], 0.46–0.75; p < 0.0001) and infectious complications (RR = 0.46; 95% CI, 0.32–0.68; p < 0.0001), and shortened the length of hospital stay (standardized mean difference, −0.49; 95% CI, −0.81 to −0.16; p = 0.0004). There was no significant between-group difference in postoperative mortality (RR = 0.46; 95% CI, 0.16–1.31; p = 0.15). Immunonutrition, mainly ω-3 fatty acids, is potentially beneficial in reducing overall and infectious postoperative complications and in shortening the hospital stay for patients undergoing hepatectomy.

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