Research Papers:

MicroRNA-466 with tumor markers for cervical cancer screening

Li-Li Zhou _, Yong Shen, Jiao-Mei Gong, Ping Sun and Jia-He Sheng

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Oncotarget. 2017; 8:70821-70827. https://doi.org/10.18632/oncotarget.19992

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Li-Li Zhou1,*, Yong Shen1,*, Jiao-Mei Gong2,*, Ping Sun1 and Jia-He Sheng1

1Department of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China

2Department of Clinical Laboratory, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

*These authors have contributed equally to this work

Correspondence to:

Li-Li Zhou, email: [email protected]

Keywords: microRNA-466, cervical cancer, tumor marker, screening, diagnoses

Received: June 20, 2017    Accepted: July 13, 2017    Published: August 07, 2017


Cervical cancer is the second most common cancer in women in the world. In this study, we explore tumor markers and microRNA-466 combination for cervical cancer screening. Tumor markers were measured by the methods of electro-chemiluminescent immunoassay and enzyme immunoassay. The microRNA-466 was performed by quantitative real-time polymerase chain reaction. Among normal group, hyperplasia group and cancer group, the CEA expression levels were 2.26 ng/ml, 3.85 ng/ml and 16.08 ng/ml, respectively. While the CA125 expression levels were 13.61 u/ml, 27.32 u/ml and 44.93 u/ml, respectively. The SCCA expression levels were 13.61 ng/ml, 27.32 ng/ml and 44.93 ng/ml, respectively. The expression levels of tumor markers were all gradually increased with the development of cervical lesions. The expression levels of microRNA-466 in cervical cancers (0.62) were greater than that in normal (0.076) and hyperplasia (0.24). The expression of microRNA-466 was correlated with lymphnode metastasis (P=0.000). There is a lower overall survival rate of patient with large tumor or lymphnode metastasis. Thus, the combination of tumor markers and microRNA-466 can be useful for early detection of cervical cancer and indicators for advanced stage and prognosis of the disease.

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