Genetic variation of lncRNA GAS5 contributes to the development of lung cancer
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Weihao Li1,*, Kai Huang2,*, Fengbiao Wen1, Guanghui Cui1, Haizhou Guo1 and Song Zhao1
1Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
2Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
*These authors have contributed equally to this work
Song Zhao, email: [email protected]
Keywords: lung cancer, lncRNA, GAS5, susceptibility
Received: May 18, 2017 Accepted: June 27, 2017 Published: August 03, 2017
Lung cancer remains the leading cause of cancer-related deaths throughout the world. In spite of great effort for the research of carcinogenesis, the molecular mechanisms of lung cancer remain unclear. In current study, we investigated the possible association between susceptibility of lung cancer and GAS5 rs145204276, which showed contradictory roles in carcinogenesis of colorectal cancer and hepatocellular carcinoma. We found that the del allele was significantly associated with 21% decreased risk of lung cancer (OR=0.79; 95% CI=0.66-0.93; P value = 0.006). Compared with the genotype ins/ins, both the genotype ins/del (OR=0.78; 95% CI=0.62-0.99) and del/del (OR=0.59;95% CI=0.39-0.89) showed decreased susceptibility of lung cancer. Real-time PCR analysis found that the expression levels of lncRNA GAS5 in lung cancer tissues were significantly lower than those in the corresponding normal tissues (P<0.01). Also the relative GAS5 expression level in samples with del/del genotype was significantly higher than that in samples with ins/del and ins/ins genotype (P<0.01). Taken together, our findings provided strong evidence for the hypothesis that GAS5 rs145204276 were significantly associated with the susceptibility of lung cancer, and GAS5 functions as a tumor suppressor in carcinogenesis of lung cancer.
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