Fluorine-18 labeled amino acids for tumor PET/CT imaging

Yiqiang Qi; Xiaohui Liu; Jun Li; Huiqian Yao; Shuanghu Yuan

doi:10.18632/oncotarget.19943

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Fluorine-18 labeled amino acids for tumor PET/CT imaging

Yiqiang Qi, Xiaohui Liu, Jun Li, Huiqian Yao and Shuanghu Yuan _

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Oncotarget. 2017; 8:60581-60588. https://doi.org/10.18632/oncotarget.19943

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Abstract

Yiqiang Qi1,2,*, Xiaohui Liu1,2,*, Jun Li4, Huiqian Yao5 and Shuanghu Yuan2,3

1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China

2Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China

3Shandong Academy of Medical Sciences, Jinan, Shandong, China

4Department of Thoracic Surgery, Shandong Provincial Hospital, Jinan, Shandong, China

5Department of Surgery, Juye Coalfield Central Hospital, Heze, Shandong, China

*Authors contributed equally to this work

Correspondence to:

Shuanghu Yuan, email: [email protected]

Keywords: Fluorine-18 labeled amino acids, positron emission tomography/computed tomography (PET/CT), tumor metabolism, molecular imaging

Received: May 25, 2017 Accepted: July 25, 2017 Published: August 04, 2017

ABSTRACT

Tumor glucose metabolism and amino acid metabolism are usually enhanced, ¹⁸F-FDG for tumor glucose metabolism PET imaging has been clinically well known, but tumor amino acid metabolism PET imaging is not clinically familiar. Radiolabeled amino acids (AAs) are an important class of PET/CT tracers that target the upregulated amino acid transporters to show elevated amino acid metabolism in tumor cells. Radiolabeled amino acids were observed to have high uptake in tumor cells but low in normal tissues and inflammatory tissues. The radionuclides used in labeling amino acids include ¹⁵O, ¹³N, ¹¹C, ¹²³I, ¹⁸F and ⁶⁸Ga, among which the most commonly used is ¹⁸F [1]. Available data support the use of certain ¹⁸F-labeled AAs for PET/CT imaging of gliomas, neuroendocrine tumors, prostate cancer and breast cancer [2, 3]. With the progress of the method of ¹⁸F labeling AAs [4–6], ¹⁸F-labeled AAs are well established for tumor PET/CT imaging. This review focuses on the current status of key clinical applications of 18F-labeled AAs in tumor PET/CT imaging.

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Fluorine-18 labeled amino acids for tumor PET/CT imaging

Abstract