Oncotarget

Research Papers:

Prognostic relevance of protein expression, clinical factors, and MYD88 mutation in primary bone lymphoma

Yong Xu, Jian Li, Jian Ouyang, Juan Li, Jingyan Xu, Qiguo Zhang, Yonggong Yang, Min Zhou, Jing Wang, Cuiling Zhang, Yueyi Xu, Ping Li, Rongfu Zhou _ and Bing Chen

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Oncotarget. 2017; 8:65609-65619. https://doi.org/10.18632/oncotarget.19936

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Abstract

Yong Xu1,*, Jian Li2,*, Jian Ouyang1, Juan Li1, Jingyan Xu1, Qiguo Zhang1, Yonggong Yang1, Min Zhou1, Jing Wang1, Cuiling Zhang1, Yueyi Xu1, Ping Li1, Rongfu Zhou1 and Bing Chen1

1Department of Hematology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

2Department of Hematology Oncology, Children’s Hospital of Nanjing Medical University, Nanjing, China

*Authors contributed equally to this work

Correspondence to:

Rongfu Zhou, email: [email protected]

Bing Chen, email: [email protected]

Keywords: primary bone lymphoma, JAK/STAT, MYD88

Received: May 25, 2017     Accepted: July 25, 2017     Published: August 04, 2017

ABSTRACT

Primary bone lymphomas (PBLs) are composed of malignant lymphoid cells presenting in osseous sites, without supra-regional lymph node or extranodal involvement. We systematically characterized the immunophenotype and the myeloid differentiation factor 88 (MYD88)-L265P gene mutation status in PBL. Clinical data from 19 patients with PBL treated at Nanjing Drum Tower Hospital between 2009 and 2015 were analyzed retrospectively. Protein expression patterns were identified immunohistochemically, and MYD88 mutation was assessed using polymerase chain reaction and direct DNA sequencing. Fifteen patients presented with diffuse large B-cell lymphoma. Clinical factors favoring a good prognosis were an age < 60 years and rituximab treatment. B-cell lymphoma 2 expression was detected in 5/15 diffuse large B-cell lymphoma patients, and was associated with a poor prognosis in a univariate model. Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling factors were upregulated in PBLs. All eighteen evaluable PBL samples harbored wild-type MYD88. These data thus suggest that age and rituximab treatment are independent prognostic factors determining overall survival, and that activation of JAK/STAT3 signaling may promote the pathogenesis of PBL. Moreover, the absence of MYD88-L265P mutation in PBL indicate there are distinct pathogenetic backgrounds among extranodal lymphomas.


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