The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis
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Peng Gao1,*, Na Niu2,*, Tianshu Wei1, Hideto Tozawa3, Xiaocui Chen1, Caiqing Zhang4, Jiandong Zhang5, Youichiro Wada3, Carolyn M. Kapron6 and Ju Liu1
1Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
2Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China
3The Research Center for Advanced Science and Technology, Isotope Science Center, The University of Tokyo, Meguro-ku, Tokyo, Japan
4Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
5Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
6Department of Biology, Trent University, Peterborough, Ontario, Canada
*These authors contributed equally to this work
Ju Liu, email: [email protected]
Keywords: STAT3, tumor angiogenesis, transcriptional regulation, endothelial cells
Received: June 28, 2017 Accepted: July 26, 2017 Published: August 04, 2017
Angiogenesis is the development of new blood vessels, which is required for tumor growth and metastasis. Signal transducer and activator of transcription factor 3 (STAT3) is a transcription factor that regulates a variety of cellular events including proliferation, differentiation and apoptosis. Previous studies revealed that activation of STAT3 promotes tumor angiogenesis. In this review, we described the activities of STAT3 signaling in different cell types involved in angiogenesis. Particularly, we elucidated the molecular mechanisms of STAT3-mediated gene regulation in angiogenic endothelial cells in response to external stimulations such as hypoxia and inflammation. The potential for STAT3 as a therapeutic target was also discussed. Overall, this review provides mechanistic insights for the roles of STAT3 signaling in tumor angiogenesis.
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