Oncotarget

Research Papers:

LncSHRG promotes hepatocellular carcinoma progression by activating HES6

Ying-Chen Xu, Chao-Jie Liang, Dong-Xin Zhang, Guan-Qun Li, Xia Gao, Jian-Zhu Fu, Feng Xia, Jia-Jun Ji, Li-Jun Zhang, Guang-Ming Li and Ji-Xiang Wu _

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Oncotarget. 2017; 8:70630-70641. https://doi.org/10.18632/oncotarget.19906

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Abstract

Ying-Chen Xu1, Chao-Jie Liang1, Dong-Xin Zhang1, Guan-Qun Li1, Xia Gao1, Jian-Zhu Fu1, Feng Xia1, Jia-Jun Ji1, Li-Jun Zhang1, Guang-Ming Li1 and Ji-Xiang Wu1

1Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Correspondence to:

Ji-Xiang Wu, email: [email protected]

Guang-Ming Li, email: [email protected]

Keywords: HCC, lncSHRG, SATB1, HES6, proliferation

Received: March 21, 2017     Accepted: July 12, 2017     Published: August 03, 2017

ABSTRACT

Hepatocellular carcinoma, one of the most common cancers, leads to mass mortality worldwide currently. However, the underlying mechanism of its oncogenesis remains to be elucidated. Here we identified that a long noncoding RNA, lncSHRG, was greatly upregulated in human hepatocellular carcinoma samples. We found that lncSHRG was essential for liver cancer cell proliferation and tumor propagation in mice. In mechanism, lncSHRG recruits SATB1 to bind to HES6 promoter and initiates HES6 expression. HES6, which is highly expressed in hepatocellular carcinoma, promotes tumor cell proliferation. High expression level of HES6 is positively correlated with clinical severity and poor prognosis of people with hepatocellular carcinoma. Altogether, our research provides a new insight on the mechanism of hepatocellular carcinoma progression.


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