Research Papers:
LncSHRG promotes hepatocellular carcinoma progression by activating HES6
PDF | HTML | Supplementary Files | How to cite
Metrics: PDF 1344 views | HTML 2036 views | ?
Abstract
Ying-Chen Xu1, Chao-Jie Liang1, Dong-Xin Zhang1, Guan-Qun Li1, Xia Gao1, Jian-Zhu Fu1, Feng Xia1, Jia-Jun Ji1, Li-Jun Zhang1, Guang-Ming Li1 and Ji-Xiang Wu1
1Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Correspondence to:
Ji-Xiang Wu, email: [email protected]
Guang-Ming Li, email: [email protected]
Keywords: HCC, lncSHRG, SATB1, HES6, proliferation
Received: March 21, 2017 Accepted: July 12, 2017 Published: August 03, 2017
ABSTRACT
Hepatocellular carcinoma, one of the most common cancers, leads to mass mortality worldwide currently. However, the underlying mechanism of its oncogenesis remains to be elucidated. Here we identified that a long noncoding RNA, lncSHRG, was greatly upregulated in human hepatocellular carcinoma samples. We found that lncSHRG was essential for liver cancer cell proliferation and tumor propagation in mice. In mechanism, lncSHRG recruits SATB1 to bind to HES6 promoter and initiates HES6 expression. HES6, which is highly expressed in hepatocellular carcinoma, promotes tumor cell proliferation. High expression level of HES6 is positively correlated with clinical severity and poor prognosis of people with hepatocellular carcinoma. Altogether, our research provides a new insight on the mechanism of hepatocellular carcinoma progression.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 19906