3D modeling of cancer stem cell niche

Jun He, Li Xiong, Qinglong Li, Liangwu Lin, Xiongying Miao, Shichao Yan, Zhangyong Hong, Leping Yang, Yu Wen and Xiyun Deng _

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Oncotarget. 2018; 9:1326-1345. https://doi.org/10.18632/oncotarget.19847

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Jun He1,*, Li Xiong1,*, Qinglong Li1, Liangwu Lin2, Xiongying Miao1, Shichao Yan3, Zhangyong Hong4, Leping Yang1, Yu Wen1 and Xiyun Deng3

1Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China

2State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, China

3Department of Pathology, Hunan Normal University Medical College, Changsha, Hunan, China

4State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China

*These authors contributed equally to this work

Correspondence to:

Leping Yang, email: [email protected]

Yu Wen, email: [email protected]

Xiyun Deng, email: [email protected]

Keywords: cancer stem cells, niche, 3D models

Received: May 18, 2017     Accepted: July 25, 2017     Published: August 03, 2017


Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models have been developed. These in vitro culture systems recapitulate the spatial dimension, cellular heterogeneity, and the molecular networks of the tumor microenvironment and show great promise in elucidating the pathophysiology of cancer stem cells and designing more clinically relavant treatment modalites.

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