Role of PLZF as a tumor suppressor in prostate cancer
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Yang Jin1, Hatice Zeynep Nenseth2 and Fahri Saatcioglu1,2
1Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway
2Department of Biosciences, University of Oslo, Oslo, Norway
Yang Jin, email: firstname.lastname@example.org
Fahri Saatcioglu, email: email@example.com
Keywords: promyelocytic leukemia zinc finger, prostate cancer, tumor suppressor, androgens
Received: March 16, 2017 Accepted: July 12, 2017 Published: August 02, 2017
The promyelocytic leukemia zinc finger (PLZF), also known as ZBTB16 (Zinc Finger And BTB Domain Containing 16), is a transcription factor involved in the regulation of diverse biological processes, including cell proliferation, differentiation, organ development, stem cell maintenance and innate immune cell development. A number of recent studies have now implicated PLZF in cancer progression as a tumor suppressor. However, in certain cancer types, PLZF may function as an oncoprotein. Here, we summarize our current knowledge on the role of PLZF in various cancer types, in particular prostate cancer, including its deregulation, genomic alterations and potential functions in prostate cancer progression.
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