Oncotarget

Research Papers:

BMI and serum lipid parameters predict increasing risk and aggressive prostate cancer in Chinese people

Ruizhe Zhao, Gong Cheng, Bing Wang, Chao Qin, Yun Liu, Yongsheng Pan, Jun Wang, Lixin Hua _, Weidong Zhu and Zengjun Wang

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Oncotarget. 2017; 8:66051-66060. https://doi.org/10.18632/oncotarget.19790

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Abstract

Ruizhe Zhao1,5,*, Gong Cheng1,*, Bing Wang4,*, Chao Qin1, Yun Liu3, Yongsheng Pan1, Jun Wang1, Lixin Hua1, Weidong Zhu2 and Zengjun Wang1

1Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

2Department of Urology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210008, China

3Department of Geratology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

4Department of Information, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

5Department of Urology, School of Medicine, The First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, China

*These authors have contributed equally to this work

Correspondence to:

Lixin Hua, email: [email protected]

Weidong Zhu, email: [email protected]

Keywords: prostate cancer, obesity, serum lipid parameters, risk, prognosis

Received: March 17, 2017    Accepted: June 29, 2017    Published: August 02, 2017

ABSTRACT

Objectives: To determine if obesity and serum lipid parameters are associated with increased risk and more aggressive prostate cancer in Chinese population

Materials and Methods: We conducted a retrospective cohort analysis including 3102 patients. Kruskal-Wallis test for continuous variables and the chi-squared tests for categorical variables were used for univariate comparison of the differences in patient characteristics across BMI categories between different groups. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for the association between prostate cancer and the various patient characteristics. Multivariable Cox proportional hazards regression was performed to assess the risk of prostate cancer recurrence

Results: 974 consecutive men were diagnosed as prostate cancer and 700 patients subsequently received radical prostatectomy immediately, and 1031 patients were pathologically diagnosed as biopsy negative. The level of low-density-lipoprotein cholesterol (LDL-c) and total cholesterol was significantly higher and the high-density-lipoprotein cholesterol (HDL-c) level is much lower in prostate cancer patients. Patients with low level of HDL-c, who subsequently received radical prostatectomy, had increased risk of high risk disease. In addition, patients with normal weight were less likely to develop a biochemical recurrence. Combined analysis revealed that obese patients had significantly higher rates of PSA recurrence over time than nonobese patients.

Conclusions: In our study, lipid parameters are supposed to be associated with prostate cancer risk and aggressiveness. Obese men are at increased risk of PSA recurrence after radical prostatectomy.


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