The construction of the multifunctional targeting ursolic acids liposomes and its apoptosis effects to C6 glioma stem cells
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Xue Ying1, Yahua Wang1, Haolun Xu1, Xia Li1, Helu Yan1, Hui Tang1, Chen Wen1 and Yingchun Li1,2
1School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, People’s Republic of China
2School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, People’s Republic of China
Xue Ying, email: [email protected]
Yingchun Li, email: [email protected]
Keywords: glioblastoma, multifunctional targeting ursolic acids liposomes, glioma stem cell, apoptosis, brain glioma-bearing mice
Received: February 06, 2017 Accepted: June 20, 2017 Published: August 02, 2017
Brain gliomas, one of the most fatal tumors to human, severely threat the health and life of human. They are capable of extremely strong invasion ability. And invasive glioma cells could rapidly penetrate into normal brain tissues and break them. We prepared a kind of functional liposomes, which could be transported acrossing the blood-brain barrier (BBB) and afterwards induce the apoptosis of glioma stem cells. In this research, we chose ursolic acids (UA) as an anti-cancer drug to inhibit the growth of C6 glioma cells, while epigallocatechin 3-gallate(EGCG) as the agent that could induce the apoptosis of C6 glioma stem cells. With the targeting ability of MAN, the liposomes could be delivered through the BBB and finally were concentrated on the brain gliomas. Cell experiments in vitro demonstrated that the functional liposomes were able to significantly enhance the anti-cancer effects of the drugs due to promoting the apoptosis and endocytosis effects of C6 glioma cells and C6 glioma stem cells at the same time. Furthermore, the evaluations through animal models showed that the drugs could obviously prolong the survival period of brain glioma-bearing mice and inhibit the tumor growth. Consequently, multifunctional targeting ursolic acids liposomes could potentially improve the therapeutic effects on C6 glioma cells and C6 glioma stem cells.
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