Family-based whole exome sequencing of atopic dermatitis complicated with cataracts

Wenxin Luo; Wangdong Xu; Lin Xia; Dan Xie; Lin Wang; Zaipei Guo; Yue Cheng; Yi Liu; Weimin Li

doi:10.18632/oncotarget.19739

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Family-based whole exome sequencing of atopic dermatitis complicated with cataracts

Wenxin Luo, Wangdong Xu, Lin Xia, Dan Xie, Lin Wang, Zaipei Guo, Yue Cheng, Yi Liu and Weimin Li _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:59446-59454. https://doi.org/10.18632/oncotarget.19739

Metrics: PDF 1348 views | HTML 2319 views | ?

Abstract

Wenxin Luo1,*, Wangdong Xu2,*, Lin Xia3, Dan Xie3, Lin Wang4, Zaipei Guo5, Yue Cheng1, Yi Liu2 and Weimin Li1

1Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China

2Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China

3State Key Laboratory of Biotherapy and Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China

4Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China

5Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China

*Wenxin Luo and Wangdong Xu contributed equally to this work, and should be considered as the co-first author

Correspondence to:

Weimin Li, email: [email protected]

Keywords: atopic dermatitis, cataracts, mutation

Received: November 07, 2016 Accepted: June 02, 2017 Published: July 31, 2017

ABSTRACT

Background: Atopic dermatitis (AD) is a common skin disorder with elevated prevalence. Cataract induced by AD rarely occurs in adolescent and young adult patients, which is also called atopic cataract. Using whole exome sequencing, we aimed to explore genetic alterations among AD and atopic cataract.

Result: We recruited a 19 year-old Chinese male with AD accompanied with cataracts, his father with AD and his mother without AD or cataract. Through analysis of the exomic sequence of the 3 individuals from the same family, we identified that with respect to AD, there were 162 genes mutated in both this patient and his father but not in his mother. In addition, we found 10 genes mutated in this patient only without in his parents according to cataract.

Conclusion: This research suggests that coinheritance of mutations in these genes may correlate with AD, and the pathogenesis of AD complicated with cataracts was related to genetic factors.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 19739

Publication Alerts

Research Papers:

Family-based whole exome sequencing of atopic dermatitis complicated with cataracts

Abstract