Oncotarget

Research Papers:

Nanofat-derived stem cells with platelet-rich fibrin improve facial contour remodeling and skin rejuvenation after autologous structural fat transplantation

Hua Wei, Shi-Xing Gu, Yi-Dan Liang, Zhi-Jie Liang, Hai Chen, Mao-Guang Zhu, Fang-Tian Xu, Ning He, Xiao-Juan Wei and Hong-Mian Li _

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Oncotarget. 2017; 8:68542-68556. https://doi.org/10.18632/oncotarget.19721

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Abstract

Hua Wei1,*, Shi-Xing Gu2,*, Yi-Dan Liang3,*, Zhi-Jie Liang4, Hai Chen4, Mao-Guang Zhu4, Fang-Tian Xu5, Ning He6, Xiao-Juan Wei7 and Hong-Mian Li6

1Department of Endocrinology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China

2Department of Burns & Plastic Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China

3Central Laboratory of Medical Science, The Fifth Affiliated Hospital of Guangxi Medical University & The First People’s Hospital of Nanning, Nanning 530022, China

4Department of Gland Surgery, The Fifth Affiliated Hospital of Guangxi Medical University & The First People’s Hospital of Nanning, Nanning 530022, China

5Department of Orthopedics, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China

6Department of Plastic and Aesthetic Surgery, The Fifth Affiliated Hospital of Guangxi Medical University & The First People’s Hospital of Nanning, Nanning 530022, China

7Department of Urinary Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China

*These authors have contributed equally to this work

Correspondence to:

Hong-Mian Li, email: 18022081568@163.com

Keywords: nanofat, nanofat-derived stem cells, stromal vascular fraction, platelet-rich fibrin, structural fat transplantation

Received: February 10, 2017    Accepted: June 19, 2017    Published: July 31, 2017

ABSTRACT

Traditional autologous fat transplantation is a common surgical procedure for treating facial soft tissue depression and skin aging. However, the transplanted fat is easily absorbed, reducing the long-term efficacy of the procedure. Here, we examined the efficacy of nanofat-assisted autologous fat structural transplantation. Nanofat-derived stem cells (NFSCs) were isolated, mechanically emulsified, cultured, and characterized. Platelet-rich fibrin (PRF) enhanced proliferation and adipogenic differentiation of NFSCs in vitro. We then compared 62 test group patients with soft tissue depression or signs of aging who underwent combined nanofat, PRF, and autologous fat structural transplantation to control patients (77 cases) who underwent traditional autologous fat transplantation. Facial soft tissue depression symptoms and skin texture were improved to a greater extent after nanofat transplants than after traditional transplants, and the nanofat group had an overall satisfaction rate above 90%. These data suggest that NFSCs function similarly to mesenchymal stem cells and share many of the biological characteristics of traditional fat stem cell cultures. Transplants that combine newly-isolated nanofat, which has a rich stromal vascular fraction (SVF), with PRF and autologous structural fat granules may therefore be a safe, highly-effective, and long-lasting method for remodeling facial contours and rejuvenating the skin.


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