Oncotarget

Research Papers:

Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer

Jongmi Lee, Ki Hyun Park, Ji Hyeong Ryu, Hyun Jin Bae, Aeran Choi, Hyeyoung Lee, Jihyang Lim, Kyungja Han, Cho Hyun Park, Eun Sun Jung and Eun-Jee Oh _

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Oncotarget. 2017; 8:70431-70440. https://doi.org/10.18632/oncotarget.19712

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Abstract

Jongmi Lee1, Ki Hyun Park2, Ji Hyeong Ryu2, Hyun Jin Bae2, Aeran Choi1, Hyeyoung Lee1,3, Jihyang Lim1, Kyungja Han1, Cho Hyun Park4, Eun Sun Jung5 and Eun-Jee Oh1

1Department of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

2Department of Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Korea

3SamKwang Medical Laboratories, Seoul, Korea

4Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

5Department of Hospital Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

Correspondence to:

Eun-Jee Oh, email: ejoh@catholic.ac.kr

Keywords: natural killer cell activity, interferon-gamma, diagnostic marker, gastric cancer

Received: May 10, 2017     Accepted: June 28, 2017     Published: July 31, 2017

ABSTRACT

Background/Aim: Decreased Natural killer cell activity (NKA) for interferon-gamma production (NKA-IFNγ) has been reported in cancer patients. The aim of this study was to determine the diagnostic performance of NKA-IFNγ for gastric cancer (GC).

Results: NKA-IFNγ levels were decreased in 261 GC patients with all stages of tumor compared to those in 48 healthy donors (P < 0.001), and lower levels of NKA-IFNγ were associated with higher GC stages. NKA-IFNγ levels were also associated with clinicopathological parameters including tumor size, depth of invasion, and lymph node metastasis. NKA-INFγ assay had better diagnostic value (AUC = 0.822) compared to serum CEA (0.624) or CA19-9 assay (0.566) (P < 0.001). Using different cut-off levels, serum CEA and CA19-9 showed sensitivities of 6.1-14.2% and 4.2-28.0%, respectively, which were much lower than that of NKA-IFNγ (55.6-66.7%).

Methods: This study included 261 patients with newly diagnosed GC and 48 healthy donors. NKA for IFNγ was determined by enzyme immunoassay after incubation of whole blood, and diagnostic performance was evaluated.

Conclusions: NK cell activities for IFNγ production could be used as a supportive non-invasive tumor marker for GC diagnosis.


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