Oncotarget

Research Papers:

Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population

Chunze Zhang, Xichuan Li, Weihua Zhang, Yijia Wang, Guanwei Fan, Wenhong Wang, Shuo Chen, Hai Qin and Xipeng Zhang _

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:72227-72234. https://doi.org/10.18632/oncotarget.19702

Metrics: PDF 1115 views  |   HTML 1547 views  |   ?  


Abstract

Chunze Zhang1,*, Xichuan Li2,*, Weihua Zhang1, Yijia Wang3, Guanwei Fan4,5, Wenhong Wang6, Shuo Chen1, Hai Qin1 and Xipeng Zhang1

1Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China

2Department of Immunology, Biochemistry and Molecular Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China

3Department of Pathology, Tianjin Union Medical Center, Tianjin 300121, China

4First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

5State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

6Department of Imaging, Tianjin Union Medical Center, Tianjin 300121, China

*These authors have contributed equally to this work

Correspondence to:

Xipeng Zhang, email: [email protected]

Keywords: colorectal cancer, rs3802842, meta-analysis, Chinese population

Received: April 18, 2017     Accepted: June 28, 2017     Published: July 31, 2017

ABSTRACT

A genome-wide association study identified a common genetic variant rs3802842 at 11q23 to be associated with CRC risk with OR=1.1 and P = 5.80E-10 in European population. In Chinese population, several genetic association studies have investigated the association between rs3802842 variant and CRC risk. However these studies reported both positive and negative association results. It is still necessary to evaluate a specific variant in a specific population, which would be informative to reveal the disease mechanism. Until recently, there is no a systemic study to evaluate the potential association between rs3802842 and CRC risk in Chinese population by a meta-analysis method. Here, we aim to evaluate this association in Chinese population by a meta-analysis method using 12077 samples including 5816 CRC cases and 6261 controls. We identified the T allele of rs3802842 to be significantly related with an increase CRC risk (P=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 19702