Oncotarget

Research Papers:

Development of a population-based cancer case-control study in southern china

Weimin Ye _, Ellen T. Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Liming Liang, Ingemar Ernberg, Thomas L. Vaughan, Guangwu Huang, Yi Zeng, Yi-Xin Zeng and Hans-Olov Adami

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Oncotarget. 2017; 8:87073-87085. https://doi.org/10.18632/oncotarget.19692

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Abstract

Weimin Ye1, Ellen T. Chang2,3, Zhiwei Liu1, Qing Liu4,5, Yonglin Cai6,7, Zhe Zhang8,9, Guomin Chen10, Qi-Hong Huang11, Shang-Hang Xie4,5, Su-Mei Cao4,5, Jian-Yong Shao5, Wei-Hua Jia5, Yuming Zheng6,7, Jian Liao12, Yufeng Chen9, Longde Lin9, Liming Liang13,14, Ingemar Ernberg15, Thomas L. Vaughan16,17, Guangwu Huang8,9,*, Yi Zeng 10,*, Yi-Xin Zeng5,18,* and Hans-Olov Adami1,13,*

1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

2Exponent, Inc., Health Sciences Practice, Menlo Park, CA, USA

3Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA

4Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China

5State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

6Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, China

7Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, China

8Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China

9Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education, Nanning, China

10State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

11Sihui Cancer Institute, Sihui, China

12Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, China

13Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA

14Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA

15Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

16Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

17Department of Epidemiology, University of Washington, Seattle, WA, USA

18Beijing Hospital, Beijing, China

*These authors have contributed equally to this work

Correspondence to:

Weimin Ye, email: [email protected]

Keywords: case-control study, nasopharyngeal carcinoma, china

Received: April 26, 2017    Accepted: July 03, 2017    Published: July 29, 2017

ABSTRACT

With its population of over 1.3 billion persons, China offers abundant opportunities to discover causes of disease. However, few rigorous population-based case-control studies have as yet been conducted in mainland China. We conducted a population-based case-control study of nasopharyngeal carcinoma in Guangdong Province and Guangxi Autonomous Region. We collected questionnaires and biospecimens from incident cases recruited between March 2010 and December 2013, and population-based controls between November 2010 and November 2014. Preparatory activities prior to subject enrollment required approximately 18 months. We enrolled a total of 2554 NPC cases and 2648 controls. Among all identified cases, 83.8% participated. For the participating cases, the median time between diagnosis and interview was 2 days. Among all contacted controls, 82.7% participated. From the enrolled cases, we collected 2518 blood specimens (provided by 98.6% of eligible cases), 2350 saliva specimens (92.0%), 2514 hair specimens (98.4%), and 2507 toenail/fingernail specimens (98.2%). From the enrolled controls, we collected 2416 blood specimens (91.2%), 2505 saliva specimens (94.6%), 2517 hair specimens (95.1%), and 2514 toenail/fingernail specimens (94.9%). We demonstrate that population-based epidemiologic research can successfully be conducted in southern China. The study protocols, databases, and biobank will serve as an extraordinarily valuable resource for testing future etiologic hypotheses.


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