Hepatitis B virus infection and decreased risk of stroke: a meta-analysis

Yaqin Wang, Jianping Xiong, Xi Chen, Meng Niu, Xiaowei Chen, Yuheng Guan, Kechuang Zheng and Ke Xu _

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Oncotarget. 2017; 8:59658-59665. https://doi.org/10.18632/oncotarget.19609

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Yaqin Wang1, Jianping Xiong2, Xi Chen3, Meng Niu1, Xiaowei Chen1, Yuheng Guan1, Kechuang Zheng1 and Ke Xu1

1Department of Interventional Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China

2Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS and PUMC), Beijing, China

3Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

Correspondence to:

Ke Xu, email: [email protected]

Keywords: hepatitis B virus, stroke, cerebrovascular disease, meta-analysis

Received: June 08, 2017     Accepted: July 13, 2017     Published: July 26, 2017


Several studies have reported that hepatitis B virus (HBV) infection may decrease the risk of stroke. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to investigate the relationship between hepatitis B virus (HBV) infection and the risk of stroke. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV infection and the risk of stroke were assessed using odds ratio (OR)/risk ratio (RR) values and the corresponding 95% confidence intervals (CIs). We used the random effects model proposed by DerSimonian and Laird to quantify the relationship. Five articles, including 834,75 HBV-infected patients and 593,949 uninfected controls, were included in the meta-analysis. The risk of stroke was significantly lower in HBV-infected patients than in uninfected controls (summary OR = 0.78; 95% CI = 0.70–0.86; I2 = 0%). However, this inverse relationship was only observed in cohort studies (OR = 0.77; 95% CI = 0.69–0.86), rather than cross-sectional study (OR = 1.10; 95% CI = 0.55–2.19). In summary, HBV infection was associated with lower risk of developing stroke.

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