Oncotarget

Research Papers:

Circulating long-chain n-3 polyunsaturated fatty acid and incidence of stroke: a meta-analysis of prospective cohort studies

Bo Yang, Xiao-Li Ren, Hong Huang, Xiao-Juan Guo, Ai-Guo Ma _ and Duo Li

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Oncotarget. 2017; 8:83781-83791. https://doi.org/10.18632/oncotarget.19530

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Abstract

Bo Yang1,2,*, Xiao-Li Ren3,*, Hong Huang2,*, Xiao-Juan Guo2, Ai-Guo Ma1 and Duo Li1

1School of Public Health, Qingdao University, Qingdao, China

2Key Laboratory of Watershed Science and Health of Zhejiang Province, School of Public Health, Wenzhou Medical University, Wenzhou, China

3The Laboratory of Animal Center, Wenzhou Medical University, Wenzhou, China

*These authors contributed equally to this work

Correspondence to:

Ai-Guo Ma, email: [email protected]

Duo Li, email: [email protected]

Keywords: biomarker, circulation, meta-analysis, PUFA, stroke

Received: February 27, 2017     Accepted: July 12, 2017     Published: July 25, 2017

ABSTRACT

Background: Circulating long-chain (LC) n-3 polyunsaturated fatty acid (PUFA) can provide objective measures that reflect both dietary consumption and relevant biological processes. Nevertheless, prospective cohort studies on circulating LC n-3 PUFA in relation to incidence of stroke have yielded inconsistent results. We therefore conducted a meta-analysis to quantitatively evaluate the association.

Results: A total of 2,836 stroke events occurred among 20,460 individuals aged 35–79 yr from 10 prospective cohort studies. Circulating LC n-3 PUFA was significantly associated with reduced risk of stroke (RR: 0.86; 95% CI: 0.76, 0.98; I2 = 0.00%), especially 22:5n-3 (RR: 0.74; 95% CI: 0.60, 0.92) and 22:6n-3 (RR: 0.78; 95% CI: 0.65, 0.94). The associations were more pronounced with ischemic stroke (RR: 0.81; 95% CI: 0.68, 0.96), but not with hemorrhagic stroke (RR: 0.95; 95% CI: 0.60, 1.49). A 1% increment of 22:5n-3 and 22:6n-3 proportions in circulating blood was associated with 25% (RR: 0.75; 95% CI: 0.64, 0.87) and 11% (RR: 0.89; 95% CI: 0.83, 0.95) reduced risk of stroke, respectively.

Materials and Methods: Pertinent studies were identified from Cochrane Library, PubMed and EMBASE database through June 2017. Multivariate-adjusted risk ratios (RRs) with 95% confidence interval (CI) for incident stroke when comparing the top with the bottom tertiles of baseline LC n-3 PUFA proportions in blood were pooled using a random-effect model.

Conclusions: Circulating LC n-3 PUFAs were linearly associated with reduced risk of stroke, especially 22:5n-3 and 22:6n-3. Such findings highlight the importance of circulating LC n-3 PUFA in the development of ischemic stroke.


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