Infiltrating mast cells enhance benign prostatic hyperplasia through IL-6/STAT3/Cyclin D1 signals
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Zhenyu Ou1, Yao He1, Lin Qi1, Xiongbin Zu1, Longxiang Wu1, Zhenzhen Cao2, Yuan Li1, Longfei Liu1, Daud Athanasius Dube3, Zhi Wang1 and Long Wang1
1Department of Urology, Xiangya Hospital, Central South University, Changsha, China
2Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, China
3Department of Urology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
Long Wang, email: email@example.com
Keywords: benign prostatic hyperplasia, mast cell, proliferation, chemokine
Received: October 19, 2016 Accepted: June 06, 2017 Published: July 22, 2017
Early evidences have showed that mast cells could infiltrate into benign prostatic hyperplasia (BPH) tissues, but the exact role of mast cells in BPH development remains unclear. In this study, we identified more mast cells existing in human BPH tissues compared with that in the normal prostate. In the in vitro co-culture system, BPH-1 prostate cells promoted activation and migration of mast cells, and mast cells conversely stimulated BPH-1 cells proliferation significantly. Molecular analysis demonstrated that mast cell-derived interleukin 6 (IL-6) could activate STAT3/Cyclin D1 signals in BPH-1 cells. Blocking IL-6 or STAT3 partially reverse the capacity of mast cells to enhance BPH-1 cell proliferation. Our findings suggest that infiltrating mast cells in BPH tissues could promote BPH development via IL-6/STAT3/Cyclin D1 signals. Therefore, targeting infiltrating mast cells may improve the therapeutic effect of BPH.
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