The correlation between renal transplantation and liver carcinoma: a meta-analysis
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Hong Yongzhi1,*, Xu Min2,*, Yu Bo3, Chen Pin3,** and Shi Xueqiang3
1Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
2Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan 215300, Jiangsu Province, China
3Department of Neurosurgery, Clinical Medical College of Yangzhou University, Subei People’s Hospital of Jiangsu province, Yangzhou 225001, Jiangsu Province, China
*These authors have contributed equally to this work and considered as co-first authors
**First corresponding author
Chen Pin, email: [email protected]
Shi Xueqiang, email: [email protected]
Keywords: meta-analysis, renal transplantation, liver carcinoma, chronic virus hepatitis, anti-virus
Received: March 07, 2017 Accepted: May 04, 2017 Published: July 22, 2017
Objective: Much of the related researches have reported the correlation between renal transplantation and different tumors in the post transplant recipients. However, there are not exact essays revealed that renal transplantation is definite causation for liver carcinoma, thus we systematically evaluated the association between renal transplantation and the risk of liver carcinoma in this meta-analysis from all available researches.
Methods: All useful data were collected through searching of PubMed and Web of Science until the date of 31 September 2015. Random-effects model were adopted to calculate the standardized incidence ratio and 95% confidence interval (CIs) of the risk of liver carcinoma among renal transplant recipients. Other statistical analyses like heterogeneity tests, sensitivity analysis and publication bias were also performed in this meta-analysis.
Results: Among 17,4256 kidney transplant cases and 25,6736 patients-years observation, 9136 post-transplant cancers were diagnosed. We identified a 2.08-fold higher standardized incidence rate (SIR) (95% confidence interval (CI): 1.24-3.47, P=0.005) of liver carcinoma following renal transplantation compared with the general population. Observation and publication bias were not observed in this study.
Conclusion: This study suggested that the risk of liver carcinoma among renal transplant recipients with chronic hepatic disease is higher than general population. Such results alert clinical doctors the importance of anti-virus therapy with chronic virus hepatitis and enough attention of periodic liver screening with chronic liver diseases in renal transplant recipients.
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