Oncotarget

Research Papers:

High expression of Ki-67 is an independent favorable prognostic factor for esophageal small cell carcinoma

Han-Yu Deng, Zi-Hang Chen, Zhi-Qiang Wang, Yun-Cang Wang, En-Min Li, Li-Yan Xu, Yi-Dan Lin and Long-Qi Chen _

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Oncotarget. 2017; 8:55298-55307. https://doi.org/10.18632/oncotarget.19426

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Abstract

Han-Yu Deng1,2,*, Zi-Hang Chen3,*, Zhi-Qiang Wang1,*, Yun-Cang Wang1, En-Min Li4, Li-Yan Xu5, Yi-Dan Lin1 and Long-Qi Chen1

1Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China

2Lung Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China

3Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

4The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area and Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong 515041, China

5The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area and Institute of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong 515041, China

*These authors contributed equally to this work and share co-first authors

Correspondence to:

Long-Qi Chen, email: [email protected]

Keywords: esophagus, small cell carcinoma, Ki-67, prognosis

Received: February 13, 2017     Accepted: July 12, 2017     Published: July 21, 2017

ABSTRACT

Background: The prognostic value of Ki-67 expression in small cell carcinoma of the esophagus (SCCE) has not been explored in any previous studies. Therefore, we conducted this retrospective study to investigate the prognostic role of Ki-67 in SCCE for the first time.

Results: A total of 44 patients were included for analysis. The baseline clinicopathological data of these SCCE patients shared similar characteristics with previous studies. Ten patients were at stage I, 17 at stage II, and the remaining 17 were at stage III. Postoperatively, 23 patients received adjuvant therapy. Twenty-eight patients were found to have a high expression of Ki-67 (> 50%). After a median follow-up time of 54.8 months, the median survival time of those patients was 22.1 months. Early TNM stage, application of adjuvant therapy, and high expression of Ki-67 (Hazard Ratio = 0.314, 95% CI: 0.127–0.774; P = 0.012) were found to be favorable prognostic factors of patients with SCCE. In subgroup analysis, adjuvant therapy could only bring significant survival benefit for patients with high expression of Ki-67 (P = 0.008).

Materials and Methods: Patients undergoing esophagectomy with lymphadenectomy for SCCE from January 2009 to January 2015 in our department were retrospectively analyzed. Data for analysis included demographic data, pathologic findings, tumor stage, adjuvant therapy, and survival time as well as Ki-67 index.

Conclusions: This study suggested that high expression of Ki-67 may not only serve as a favorable prognostic factor of SCCE but also an indication of providing adjuvant therapy for SCCE patients with surgical resection.


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